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Moumoujus

NICOTIANA TABACUM LEAF EXTRACT.

Questionable CAS 84961-66-0 / PERFUMING, SKIN CONDITIONING

Nicotiana Tabacum Leaf Extract offers multi-functional benefits, primarily acting as a potent antioxidant to combat oxidative stress and support cellular health. It also functions as a skin conditioning agent, promoting softer, smoother, and more hydrated skin.

Summary

Antioxidant Skin Conditioning Antimicrobial Perfuming

Science

Mechanism of Action

This extract operates through several mechanisms: it actively scavenges free radicals and reduces oxidative stress, thereby mitigating cellular aging and inflammatory responses. Key components, such as nicotine, are implicated in activating anti-inflammatory pathways. Additionally, it provides skin conditioning effects, enhancing skin texture and hydration, and has demonstrated antimicrobial properties.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies demonstrate significant antioxidant capacity of tobacco leaf waste extracts (1.6-5 µg GAE/mL for ABTS SC50; 3.8-8.7 µg GAE/mL for H2O2 SC50), effectively reducing oxidative stress and potentially mitigating cellular aging and inflammation.
  2. 02 A 1% concentration of Oriental tobacco resinoid has exhibited antimicrobial activity when incorporated into a cosmetic gel model.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 3.5 – 7
0 7 14

Stability

The extract maintains stability within a pH range of 3.5 to 7. To preserve its integrity, processing temperatures should not exceed 60°C during formulation. Advanced extraction methods utilizing Natural Deep Eutectic Solvents (NaDES) have also demonstrated enhanced chemical and thermal stability for its bioactive components.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While formal safety assessments by CIR or SCCS are absent, studies on systemic exposure to tobacco leaf extract, particularly its nicotine content, indicate potential health hazards, with lethal doses of nicotine noted (0.5-1 mg/kg body weight in humans). Animal studies highlight concerns regarding hematological indices and organ health. Dermal exposure in mice has shown an 'injury effect' and 'oxidative stress activities,' primarily attributed to nicotine. Although topical side effects are generally uncommon, a patch test is recommended due to a reported 'medium' irritancy. Use during pregnancy or breastfeeding lacks sufficient data, and professional medical advice is strongly advised.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Questionable

Despite exhibiting in vitro antioxidant and antimicrobial properties, the considerable safety concerns related to its nicotine content, lack of extensive topical safety data, and reported moderate irritancy render this ingredient highly questionable for precision skincare formulations.

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