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Moumoujus

NICKEL GLUCONATE.

Avoid CAS - / NOT REPORTED

Nickel Gluconate is recognized for its humectant properties, theoretically aiding skin hydration by attracting and retaining moisture. However, its identity as a nickel salt presents substantial concerns, primarily linked to its documented potential as an allergen and an inducer of inflammatory responses within skin cells.

Summary

Humectant

Science

Mechanism of Action

As a humectant, Nickel Gluconate is believed to contribute to the skin's moisture retention capabilities. Mechanistically, in vitro research suggests that the nickel ion can activate keratinocytes, initiating a cascade that leads to the release of various inflammation markers. This activation may occur through the stimulation of the lipoxygenase pathway and the activation of protein kinase C.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies demonstrate maximal keratinocyte activation, significantly enhancing the production of key inflammation markers such as intracellular adhesion molecule-1, tumor necrosis factor-alpha, and very late antigen-3.

Transparency

Dusting Analysis

Commonly dusted

Nickel gluconate is listed as a potential impurity in various cosmetic products. Given its severe hazard profile, any presence, even as an impurity, is a significant concern.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk High

Nickel Gluconate is a California Safe Cosmetics Program (CSCP) Reportable Ingredient, identified for hazard traits including carcinogenicity, reproductive toxicity, and respiratory toxicity. It is categorized as a Group 1 carcinogen by IARC and listed on California's Prop 65. Furthermore, it is a REACH Restricted Substance in the European Union. GHS classifications highlight severe risks: H317 (May cause an allergic skin reaction), H334 (May cause allergy or asthma symptoms or breathing difficulties if inhaled), H341 (Suspected of causing genetic defects), H350i (May cause cancer by inhalation), H360D (May damage the unborn child), and H372 (Causes damage to organs through prolonged or repeated exposure).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Moumoujus strongly advises against the use of Nickel Gluconate in skincare formulations due to its severe classification as a confirmed human carcinogen, reproductive toxicant, and potent allergen, despite its purported humectant function.

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