Science
Mechanism of Action
Neosaxitoxin functions as a site-1 specific blocker of voltage-gated sodium channels. By binding to the extracellular vestibule of these channels, it effectively prevents the influx of sodium ions, thereby inhibiting the initiation and propagation of action potentials in neurons and other excitable cells. This mechanism leads to the cessation of nerve signaling, resulting in anesthetic and paralytic outcomes.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
Given its classification as a potent neurotoxin and acutely fatal substance, Neosaxitoxin is entirely unsuitable for any cosmetic application, rendering the concept of 'dusting' irrelevant and profoundly hazardous.
The Formula
Formulation
Stability
This compound is highly hydrophilic and thermostable, maintaining significant potency for at least 18 months when stored in dilute acidic solutions, particularly at a pH of 3-4. However, its stability decreases notably at higher pH values, showing degradation at pH 6-7 at 25°C.
Safety
Safety Profile
Neosaxitoxin is an extremely potent neurotoxin, acutely toxic, and classified as fatal if swallowed. The oral lethal dose (LD50) for a related compound, saxitoxin, is approximately 0.57 mg in humans. It is not approved by the FDA for cosmetic use, with its designation explicitly prohibiting such marketing. It is strictly regulated as a marine toxin due to its potential to cause paralytic shellfish poisoning, and its extreme toxicity has precluded review for cosmetic application by organizations like CIR or SCCS.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Neosaxitoxin is an extremely toxic neurotoxin with a 'fatal if swallowed' classification and no FDA approval for cosmetic use, making it unequivocally unsafe and unsuitable for any skincare formulation.
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References
Sources