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Moumoujus

NEOMENTHOL.

Valuable CAS 3623-51-6 / PERFUMING

Neomenthol is a naturally occurring compound primarily recognized for its immediate cooling sensation upon skin contact, mediated by specific cellular interactions. Beyond its refreshing properties, scientific investigations indicate its potential for advanced biological actions, including anti-inflammatory, analgesic, and significant antiproliferative activities.

Summary

cooling agent fragrance ingredient masking potential anti-inflammatory potential analgesic potential hyaluronidase inhibitor potential antiproliferative

Science

Mechanism of Action

Neomenthol's characteristic cooling sensation is initiated by its specific binding to TRPM8 receptors found on skin cells. This interaction elicits a cool, fresh feeling. Furthermore, research demonstrates its capacity to influence cellular processes by inhibiting tubulin polymerization and reducing hyaluronidase activity, pathways known to be involved in cell proliferation, tissue remodeling, and inflammation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In laboratory studies, Neomenthol exhibited promising antiproliferative activity against human epidermoid carcinoma (A431) cells, demonstrating an IC50 of 17.3 ± 6.49 µM. It induced G2/M cell cycle arrest and increased sub-diploid cell populations. Additionally, it significantly inhibited hyaluronidase activity with an IC50 of 12.81 ± 0.01 µM and was observed to affect tubulin polymerization.
  2. 02 An in vivo animal study utilizing an intraperitoneal dose of 75 mg/kg body weight demonstrated a 58.84% prevention of Ehrlich ascites carcinoma (EAC) tumor formation, along with up to 10% inhibition of hyaluronidase activity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Neomenthol is considered stable when stored under recommended conditions, allowing for consistent performance in formulated products.

Conflicts

  • strong oxidizing agents
  • butyl chloral hydrate
  • camphor
  • phenol
  • chloral hydrate
  • Exalgine
  • betanaphthol
  • resorcinol
  • thymol (in triturations)
  • potassium permanganate
  • chromium trioxide
  • pyrogallol

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

D-NEOMENTHOL is recognized as generally recognized as safe (GRAS) by the FDA for use in food and is listed as an IFRA Fragrance Ingredient. However, aggregated GHS information indicates potential for skin irritation (H315) and serious eye irritation (H319). Exposure may lead to irritation of the skin, eyes, mucous membranes, and upper respiratory tract, and it carries a risk of skin sensitization. An acute oral toxicity study found an oral dose of 1000 mg/kg bw to be safe.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Neomenthol is a valuable ingredient for its established cooling effects and intriguing potential in advanced biological pathways relevant to precision skincare, though its formulation must carefully navigate identified risks of irritation and sensitization.

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