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N,N-DIMETHYL-P-PHENYLENEDIAMINE SULFATE.

Avoid CAS 6219-73-4 / HAIR DYEING

N,N-Dimethyl-p-phenylenediamine Sulfate functions primarily as a precursor in oxidative hair dyeing processes. However, its direct application to skin carries a significant risk of sensitization and irritation, making it unsuitable for dermal cosmetic formulations.

Summary

Hair Dye Precursor (Industrial) Analytical Reagent (Laboratory) Dye Production Intermediate (Industrial)

Science

Mechanism of Action

In hair dyeing, this compound acts as a chromophore precursor, undergoing oxidation by hydrogen peroxide to form larger, color-imparting molecules that embed within hair fibers. On human skin, its mechanism of action is linked to potential sensitization, where competitive N-acetylation and conditions that promote auto-oxidation can induce dermal irritation and immune responses.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

This compound is not associated with beneficial active properties in skincare, nor is it typically used in 'dusted' concentrations. Its substantial safety concerns, including high irritancy and sensitization risk, dictate its exclusion from consumer skincare formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The ingredient is highly sensitive to light, air, and heat, requiring stringent storage conditions under inert gas and refrigeration (0-10°C) to prevent discoloration and maintain stability.

Conflicts

  • Acids
  • Strong oxidizing agents
  • Acid anhydrides
  • Acid chlorides
  • Chloroformates

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
4%
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel deemed p-Phenylenediamine Sulfate (a broader category including this ingredient) safe for hair dye use within specific parameters, with a maximum concentration of 4% (calculated as free base) in the finished product, or 2% when mixed with hydrogen peroxide. Crucially, it is considered unsafe for direct dermal coloring applications (e.g., temporary tattoos) and for use in eyelash and eyebrow dyes. It is explicitly indicated for professional manufacturing, research laboratories, and industrial/commercial usage only, not for medical or consumer use in the US, and is classified as hazardous by OSHA.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

N,N-Dimethyl-p-phenylenediamine Sulfate poses a high risk of dermal sensitization and irritancy, with explicit warnings against consumer and medical skin contact, rendering it entirely unsuitable for precision skincare formulations.

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