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N,N-DIETHYL-P-PHENYLENEDIAMINE.

Avoid CAS 93-05-0 / HAIR DYEING

N,N-DIETHYL-P-PHENYLENEDIAMINE is an organic chemical primarily utilized as a reactive intermediate in permanent hair dye systems and as a color coupler in photographic development. Despite its industrial applications, this compound is associated with significant adverse effects on human skin, including severe irritation, dermatitis, and chemical burns.

Summary

Science

Mechanism of Action

While primarily functioning as a key intermediate in permanent hair dyeing by reacting with hydrogen peroxide to fix color, and as a color coupler in photographic processes, N,N-DIETHYL-P-PHENYLENEDIAMINE offers no beneficial mechanism for direct skin application. Upon contact, this ingredient provokes a strong inflammatory cascade, leading to severe irritation, dermatitis, and potential tissue damage.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This compound is highly sensitive to both air and light, necessitating protection from direct exposure to these elements and excessive heat to preserve its integrity. With a conjugate acid pKa of 7.96, it will predominantly exist in its ionized form within the typical cosmetic pH range of 5 to 9.

Conflicts

  • acids
  • isocyanates
  • halogenated organics
  • peroxides
  • phenols (acidic)
  • epoxides
  • anhydrides
  • acid halides
  • strong oxidizing agents
  • strong acids

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0%
Sensitization risk High

N,N-DIETHYL-P-PHENYLENEDIAMINE has not been directly assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. However, related phenylenediamine compounds, such as p-Phenylenediamine (PPD), have been reviewed; the CIR found PPD safe for hair dyes up to 2% (as free base) but unsafe for direct dermal applications like temporary tattoos. The Scientific Committee on Consumer Safety (SCCS) has designated p-phenylenediamine as an 'extreme sensitiser,' underscoring a significant risk of allergic reactions. Globally Harmonized System (GHS) classifications for N,N-DIETHYL-P-PHENYLENEDIAMINE include 'Harmful in contact with skin' and 'Causes severe skin burns and eye damage' (H314), with a further classification of 'Toxic if swallowed' (H301). The U.S. FDA regulates coal-tar hair dyes, which encompass phenylenediamines, requiring specific caution statements and patch test instructions.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

N,N-DIETHYL-P-PHENYLENEDIAMINE is an ingredient to be strictly avoided in skincare formulations due to its severe potential for skin irritation, dermatitis, and chemical burns, with a maximum recommended concentration of 0%.

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