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N,N-DIETHYL-M-AMINOPHENOL SULFATE.

Avoid CAS 68239-84-9 / HAIR DYEING

N,N-DIETHYL-M-AMINOPHENOL SULFATE is an aminophenol derivative, primarily identified for its function as a coupler in oxidative hair dyeing processes. Its chemical properties allow it to act as a fluorescent probe and participate in nucleophilic substitutions, forming stable covalent adducts. This ingredient's principal applications lie in the dye industry, with limited direct relevance to precision skincare.

Summary

Dye Coupler Fluorescent Probe Crosslinking Agent

Science

Mechanism of Action

This compound, derived from N,N-Diethyl-3-aminophenol, primarily engages in nucleophilic substitution reactions, interacting with electron-rich aromatic compounds to generate stable covalent adducts. It can also serve as a crosslinking agent for biomolecules. In the context of oxidative hair coloring, it acts as a coupler, reacting with dye precursors and an oxidizing agent, typically hydrogen peroxide, to produce color molecules that penetrate and color the hair shaft.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No information indicates this ingredient is commonly associated with consumer 'dusting' or widespread misinformation.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The parent compound, N,N-Diethyl-3-aminophenol, exhibits sensitivity to both air and heat, necessitating refrigerated storage between 0-10°C under an inert gas. As an amine, it functions as a chemical base, neutralizing acids exothermically. Its phenolic structure contributes weak organic acid properties, rendering it incompatible with strong reducing substances.

Conflicts

  • isocyanates
  • halogenated organics
  • peroxides
  • phenols (acidic)
  • epoxides
  • anhydrides
  • acid halides
  • strong reducing substances (hydrides, nitrides, alkali metals, sulfides)
  • strong acids
  • strong bases

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
For related aminophenol salts (e.g., m-Aminophenol, o-Aminophenol) in oxidative hair colorants, EU regulations provisionally permit concentrations up to 2% when used alone, or 1% when combined with hydrogen peroxide. No specific maximum concentration for skin applications is available.%
Sensitization risk Unknown

A specific CIR review for N,N-DIETHYL-M-AMINOPHENOL SULFATE is not available. The base compound, N,N-Diethyl-m-aminophenol (CAS 91-68-9), is classified with GHS 'Danger' pictograms and hazard statements including 'Toxic if swallowed', 'Causes skin irritation', 'Causes serious eye irritation', and 'May cause respiratory irritation'. Conflicting data exists regarding its irritancy; while IUCLID indicates 'Not a skin or eye irritant in rabbits' and 'Not sensitizing in skin painting study of guinea pigs', Sigma-Aldrich MSDS states 'A skin and strong eye irritant'. This contradictory information warrants significant caution.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to significant safety warnings, conflicting data regarding irritation potential for its base compound, and its primary utility as a dye intermediate rather than a skincare active, N,N-DIETHYL-M-AMINOPHENOL SULFATE is not suitable for precision skincare formulations.

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