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Moumoujus

MYRISTOYL GLUTAMIC ACID.

Valuable CAS 53576-52-6 / HAIR CONDITIONING, SKIN CONDITIONING

Myristoyl Glutamic Acid, an amide derived from myristoyl chloride and glutamic acid, functions primarily as a skin conditioning agent. It targets damaged or dry skin to reduce flakiness and enhance elasticity, while its sodium salt variant also offers gentle cleansing, emulsifying, and barrier-supporting properties.

Summary

Cleansing Surfactant Skin Conditioning Hair Conditioning Emulsifying

Science

Mechanism of Action

This ingredient operates as a skin conditioning agent by specifically targeting compromised or dehydrated skin, working to diminish flakiness and restore suppleness. Its sodium salt, Sodium Myristoyl Glutamate, extends its utility by acting as a mild surfactant, emulsifier, and cleansing agent, contributing to improved product texture, enhanced formulation stability, and crucial maintenance of the skin's inherent barrier function, potentially boosting the efficacy of co-formulated active ingredients.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 7
0 7 14

Stability

Myristoyl glutamic acid exhibits very low estimated water solubility (0.889 mg/L at 25 °C) with an estimated LogP (o/w) of 4.140, confirming its primary oil solubility. Its sodium salt maintains optimal stability within a pH range of 5 to 7, particularly in sulfate-free formulations. It's important to note that glutamic acid, a precursor, can convert to pyrrolidonecarboxylic acid at intermediate pH values, which could impact the ingredient's form or function over time.

Conflicts

  • May be sensitive to high temperature, humidity, and pressure during compression (general amino acid consideration).
  • Potential for conversion of glutamic acid to pyrrolidonecarboxylic acid at intermediate pH values.
  • Possible incompatibility with reducing sugars due to Maillard reactions (as an amino acid derivative).

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has determined this ingredient, along with 114 other amino acid alkyl amides, to be safe for use in cosmetics under current practices and concentrations, provided formulations are designed to be non-irritating.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Myristoyl Glutamic Acid is a valuable skin conditioning agent and mild surfactant, demonstrating broad skin compatibility and a low irritancy risk, particularly beneficial for damaged or dry skin.

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