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Moumoujus

MYRISTOYL DIPEPTIDE-12 AMIDE.

Insufficient Data / ANTIMICROBIAL

MYRISTOYL DIPEPTIDE-12 AMIDE is a modified peptide recognized for its antimicrobial properties. The strategic attachment of a myristoyl fatty acid group significantly increases its hydrophobicity, enabling enhanced penetration across the skin's lipid barrier for more direct cellular uptake.

Summary

Antimicrobial Skin Conditioning

Science

Mechanism of Action

This precision peptide functions primarily as an antimicrobial agent. As an endogenous protein building block, it also signals to activate the skin's natural repair mechanisms. The myristoyl group, a fatty acid component, augments the peptide's hydrophobicity, facilitating its efficient translocation across the lipid bilayer and enhancing cellular absorption within the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Peptide stability is generally pH-dependent. Amide bond cleavage can occur via direct hydrolysis, which tends to be more prevalent at pH 10, or through intramolecular aminolysis ('backbiting'), which is more pronounced at neutral pH. Both degradation mechanisms are significant in acidic conditions around pH 3. The myristoyl group contributes to increased hydrophobicity, rendering these peptides sparingly soluble in aqueous buffers (e.g., approximately 0.25 mg/ml in a 1:3 ethanol:PBS solution at pH 7.2 for a related peptide) and notably more soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (around 30 mg/ml).

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

MYRISTOYL DIPEPTIDE-12 AMIDE has not undergone specific review by the Cosmetic Ingredient Review (CIR), indicating its safety status is 'not reviewed'. While related 'Alkyl Amide MIPA Ingredients' have been deemed safe in non-irritating cosmetic formulations, broader CIR discussions on other peptides have raised questions about potential drug-like activity and the need for comprehensive reproductive/developmental toxicity data; however, these specific concerns do not directly apply to MYRISTOYL DIPEPTIDE-12 AMIDE itself.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While MYRISTOYL DIPEPTIDE-12 AMIDE presents a promising mechanism as an antimicrobial agent with enhanced skin penetration, comprehensive data on its specific clinical efficacy and detailed safety profile for cosmetic use remain limited.

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