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MYRISTAMIDOPROPYLAMINE OXIDE.

Valuable CAS 67806-10-4 / ANTISTATIC, CLEANSING, HAIR CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - FOAM BOOSTING, SURFACTANT - HYDROTROPE

Myristamidopropylamine Oxide is an amphiphilic surfactant that effectively cleanses skin and hair by reducing surface tension and lifting impurities. It also functions as a foam booster and hair conditioning agent, enhancing product aesthetics and hair manageability.

Summary

Antistatic Cleansing Foam Boosting Hair Conditioning Hydrotrope Surfactant

Science

Mechanism of Action

This ingredient operates as a surfactant, utilizing its amphiphilic structure, comprising a hydrophobic C14 alkyl chain and a hydrophilic amine oxide headgroup, to decrease water's surface tension. This action facilitates the removal of dirt, oil, and impurities from skin, hair, and teeth. Furthermore, it significantly improves foam quality, volume, texture, and durability. Beyond its cleansing capabilities, it acts as a hair conditioning agent, promoting easier combing, softness, suppleness, and shine, while also providing antistatic benefits. Its hydrotropic properties can enhance the solubility of other compounds. Its chemical behavior is pH-dependent, exhibiting nonionic characteristics at neutral to alkaline pH, and becoming protonated (cationic) below its pKa of approximately 4.5. Additionally, it may contribute antimicrobial activity through microbial membrane disruption.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Myristamidopropylamine Oxide demonstrates robust thermal stability under standard storage conditions. While its N-oxide group is inherently stable, the amide bond is susceptible to hydrolysis, catalyzed by both acidic and basic extremes. Degradation can occur from exposure to strong oxidizing or reducing agents, or elevated temperatures with oxygen. Its charge profile is pH-dependent, shifting from predominantly nonionic at neutral and alkaline pH to cationic below its pKa of approximately 4.5, supporting its solubility across a wide pH spectrum.

Conflicts

  • strong oxidizing agents
  • strong reducing agents
  • extreme pH (can catalyze amide bond hydrolysis)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed Myristamidopropylamine Oxide. However, a related compound, Cocamidopropylamine Oxide, was deemed not a primary dermal irritant or skin sensitizer at a 5% solution and used safely in formulations up to 4.0%. A 7.5% solution of Cocamidopropylamine Oxide produced mild irritation but no sensitization. Myristamidopropylamine Oxide is generally regarded as mild, and the EPA Safer Chemical program has categorized it as low concern based on experimental and modeled data. While GHS classifications for the raw material indicate potential for skin irritation (H315) and serious eye damage (H318), its irritation potential in cosmetic applications is considered low at concentrations up to approximately 5%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Myristamidopropylamine Oxide is a valuable, versatile surfactant, effective for cleansing and conditioning across various skin and hair types, with a generally low irritation potential when formulated appropriately.

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