Science
Mechanism of Action
The mechanism of action is primarily attributed to Myricetin, the parent compound. It acts as a robust antioxidant by directly scavenging free radicals and suppressing UV-induced oxidative stress in keratinocytes. Its photoprotective and anti-photoaging effects stem from its ability to inhibit UVB-induced angiogenesis, reduce wrinkle formation, and downregulate matrix metalloproteinase-9 (MMP-9) expression, alongside attenuating Raf-kinase, MEK, and ERK phosphorylation. Myricetin also exhibits anti-inflammatory properties by inhibiting key pro-inflammatory mediators suchs as NF-κB, IL-6, IL-12, NO, iNOS, TNF-α, COX-2, and PGE2, which helps to reduce UVB-induced keratinocyte apoptosis. Furthermore, Myricetin has been shown to inhibit collagenase activity within human dermal fibroblasts.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Myricetin demonstrated 12.7% collagenase inhibition in human dermal fibroblasts at a concentration of 0.1 mM (32 µg/mL), increasing to 29.6% inhibition at 0.2 mM (64 µg/mL). (Data refers to Myricetin, the parent compound).
- 02 Myricetin at 20 μM significantly reduced Akt activity and stimulated apoptosis in UVB-irradiated HaCaT keratinocyte cells, indicating a role in mitigating sun-induced cellular damage. (Data refers to Myricetin, the parent compound).
- 03 Myricetin at 10 μM and 20 μM inhibited phorbol ester-induced COX-2 expression through the suppression of NF-κB activation in JB6 P+ mouse epidermal cells, highlighting its anti-inflammatory potential. (Data refers to Myricetin, the parent compound).
- 04 Myricetin Nanofibers (MyNF) demonstrated enhanced water solubility and improved skin penetration, leading to superior antioxidant and photoprotective activity compared to raw Myricetin against UVB-induced damage in HaCaT keratinocytes. (Data refers to Myricetin Nanofibers).
- 05 Myricetin suppressed the phosphorylation of EGFR and AKT, and downregulated the expression of inflammatory markers like Mmp9, Ptgs2, and Tnf, suggesting multi-target anti-psoriatic effects. (Data refers to Myricetin, the parent compound).
- 06 Myricetin inhibited UV-induced angiogenesis by targeting PI3-K in an SKH-1 hairless mouse skin tumorigenesis model, suggesting a role in mitigating UV-induced skin aging effects. (Data refers to Myricetin, the parent compound).
Transparency
Dusting Analysis
The provided research does not contain specific information regarding the common practice of 'dusting' this ingredient or relevant threshold percentages for Myricetin Sesquipropionate.
The Formula
Formulation
Stability
The parent compound, Myricetin, demonstrates optimal stability at a pH of 2.0. Its stability is highly dependent on both pH and temperature, with rapid degradation observed under basic pH conditions. It maintains good stability when exposed to UV radiation. Stability can be further enhanced by the addition of 0.1% antioxidants. Myricetin is poorly water-soluble (typically less than 5 µg/mL); however, its solubility can be significantly improved using advanced delivery systems such as nanofiber technology or inclusion complexation with cyclodextrins.
Synergies
- Antioxidants (e.g., 0.1%) to enhance stability
Conflicts
- Basic substances (due to rapid degradation of Myricetin)
- Certain organic solvents (e.g., methanol, ethanol, DMSO) if not carefully selected and removed, due to potential skin irritation
Safety
Safety Profile
No formal regulatory safety assessments (CIR, SCCS, or FDA status) were identified for Myricetin Sesquipropionate or its parent compound, Myricetin, specifically as a cosmetic ingredient. While some studies suggest Myricetin Nanofibers are 'safe' for topical application and Myricetin itself has potential as a 'safe and effective natural therapeutic agent,' these are not official regulatory declarations for general cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While the parent compound Myricetin exhibits promising efficacy across various skin benefits, direct clinical data and comprehensive safety assessments specifically for Myricetin Sesquipropionate are currently insufficient to establish its definitive role and recommended usage in skincare formulations.
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References
Sources