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Moumoujus

MYRICETIN SESQUICAPRYLATE.

Insufficient Data / SKIN CONDITIONING

Myricetin Sesquicaprylate is an esterified derivative of Myricetin, a naturally occurring flavonoid. This modification likely enhances its oil solubility for cosmetic applications while aiming to deliver the parent compound's established antioxidant, anti-inflammatory, and photoprotective properties to the skin.

Summary

Antioxidant Anti-inflammatory Photoprotective

Science

Mechanism of Action

Myricetin, the active flavonoid component, protects the skin by reducing oxidative stress through scavenging reactive oxygen species (ROS) and inhibiting UV-induced keratinocyte damage. It also effectively mitigates skin inflammation by decreasing the production of inflammatory cytokines and chemokines within keratinocytes. Additionally, Myricetin modulates thermogenic regulatory proteins and balances the TIMP/MMPs ratio, alongside inhibiting several kinase activities implicated in cell transformation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 2 – 3
0 7 14

Stability

Optimal stability for Myricetin, the parent compound, is observed within a narrow pH range of 2.0 to 3.0. Its degradation is significantly influenced by both temperature and pH, showing rapid breakdown under basic conditions, with pH 8 identified as the least stable point. The ingredient is also labile when exposed to strong oxidizing agents, but its stability can be enhanced by the co-formulation with antioxidants such as ascorbic acid and sodium metabisulfite. Myricetin is particularly vulnerable to autooxidation when pH exceeds 7.4.

Synergies

  • Ascorbic acid
  • Sodium metabisulfite

Conflicts

  • Strong oxidizing agents
  • Basic pH (>7.4)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

As of current data, Myricetin Sesquicaprylate has not been reviewed for safety by CIR, SCCS, or FDA. The parent compound, Myricetin, is a natural flavonoid found in various foods and is classified as non-hazardous for laboratory use at ≥95% purity. However, a significant concern is Myricetin's susceptibility to autooxidation at pH values above 7.4, which can lead to the generation of reactive oxygen species (ROS) and potentially exert toxic effects on biomolecules.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While the parent compound, Myricetin, demonstrates promising antioxidant and anti-inflammatory properties, there is insufficient specific data regarding the safety and clinical efficacy of Myricetin Sesquicaprylate, especially considering the parent's pH-dependent stability issues.

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