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Moumoujus

MORPHOLINE STEARATE.

Avoid CAS 22707-25-1 / CLEANSING, SURFACTANT - CLEANSING

Morpholine Stearate is a chemical salt formed from morpholine, an amine, and stearic acid, a common fatty acid. In cosmetic formulations, it is primarily intended to function as an emulsifier and surfactant, stabilizing immiscible oil and water phases.

Summary

Emulsifying Surfactant Emollient Skin Conditioning Viscosity Controlling pH Adjustor

Science

Mechanism of Action

Operating as an amphiphilic molecule, Morpholine Stearate effectively reduces interfacial tension between disparate liquid phases, thereby facilitating the formation and stabilization of emulsions. The morpholine component can also contribute to pH adjustment, while the stearic acid moiety imparts emollient properties and structural body to cosmetic preparations.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Exhibiting amphiphilic characteristics, Morpholine Stearate is expected to demonstrate solubility in both aqueous and organic solvents. While morpholine itself is thermally stable up to 288°C, the stability of the fatty acid salt can be influenced by alkaline pH. A critical formulation imperative is the stringent avoidance of nitrosating agents to preclude the formation of N-nitrosomorpholine.

Conflicts

  • Nitrosating agents (due to potential N-nitrosomorpholine formation)
  • Certain active pharmaceutical ingredients (APIs) such as aspirin, glimepiride, cephalexin, glipizide, and doxylamine succinate.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that the safety of morpholine itself, the amine component, lacks sufficient documentation, rendering it unsafe for cosmetic use without further substantiated data. A significant toxicological concern is its potential to react with nitrosating agents, forming N-nitrosomorpholine, which is identified as mutagenic. Morpholine Stearate specifically lacks a dedicated CIR safety assessment, unlike many other stearate salts. The SCCS has also highlighted the importance of basicity in controlling nitrosation rates of secondary amines like morpholine. Its listing by the FDA as a food additive does not extend to its safety for cosmetic applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to insufficient safety data for its morpholine component and the critical risk of forming mutagenic N-nitrosomorpholine, this ingredient is not recommended for cosmetic applications by Moumoujus.

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