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Moumoujus

MORPHOLINE OLEATE.

Insufficient Data CAS 1095-66-5 / CLEANSING, SURFACTANT - CLEANSING

Morpholine Oleate is an amphiphilic amine salt derived from morpholine and oleic acid, primarily functioning as a surfactant and emulsifier. It effectively reduces interfacial tension, enabling the creation of stable oil-in-water formulations, and also acts as a cleansing agent.

Summary

Surfactant Emulsifier Cleansing Agent Dispersing Agent Lubricant

Science

Mechanism of Action

Morpholine Oleate operates by leveraging its amphiphilic structure, which features a hydrophilic morpholine head and a lipophilic oleic acid tail. This characteristic allows it to significantly reduce interfacial tension between immiscible phases, thereby stabilizing emulsions as a surfactant and emulsifier. The oleic acid component is also recognized for its ability to enhance skin penetration by influencing the lipid organization within the stratum corneum, while the compound additionally serves as a cleansing agent.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 No human topical skin efficacy studies for Morpholine Oleate were identified in the provided research data. Animal studies focused on systemic effects: mice administered 0.25% and 1.0% in drinking water showed growth retardation, and a no observed adverse effect level (NOAEL) of 400 mg/kg bw/day was determined in mice for kidney health, with adverse effects observed at 700 mg/kg bw/day.

Transparency

Dusting Analysis

Not commonly dusted

Morpholine Oleate functions primarily as a surfactant and emulsifier rather than a skin active with a defined therapeutic dose. Therefore, the concept of 'dusting' at low concentrations for efficacy does not directly apply based on available data.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Morpholine Oleate is readily soluble and miscible in water but is susceptible to oxidation. Optimal emulsion stability requires careful pH adjustment, although a specific ideal pH range is not detailed. High storage temperatures can also compromise emulsion integrity.

Conflicts

  • Strong oxidizing agents, which can lead to combustion.
  • Higher concentrations of oleic acid, a component of Morpholine Oleate, may exhibit limited compatibility with certain phospholipids, potentially causing phase separation.
  • Based on its parent compound Morpholine, it should be avoided with strong acids, cellulose nitrate, nitromethane, other nitro compounds, and is known to be corrosive to metals.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) has not specifically assessed Morpholine Oleate, though its parent compound, Morpholine, has been reviewed. The U.S. FDA permits Morpholine and its fatty acid salts in certain food-contact applications as corrosion inhibitors. Aggregated GHS data indicates that approximately 22.4% of reports classify it as a skin and serious eye irritant (H315, H319), warranting a 'Warning' signal, while the majority (77.6%) do not classify it as a GHS hazard. The parent compound, Morpholine, is known to be corrosive and a strong irritant due to its high pH.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Morpholine Oleate acts as an effective emulsifier and cleansing agent, its lack of specific CIR review for cosmetic use, coupled with potential irritation and limited data on topical skin efficacy, indicates insufficient information for a definitive positive verdict in precision skincare formulations.

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