Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

MONASCUS/ANGELICA KEISKEI LEAF/SOYBEAN FERMENT FILTRATE.

Valuable / ANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING

This innovative ingredient harnesses the synergistic power of Monascus-fermented soybean extract and Angelica keiskei leaf. It is precisely engineered to offer multifaceted benefits, targeting skin aging, oxidative stress, and hyperpigmentation through its advanced bio-active compounds. This unique filtrate promotes a more even, youthful complexion.

Summary

Antioxidant Skin Brightening Anti-aging Melanin Reduction Tyrosinase Inhibition Elastase Inhibition Cellular Regeneration Anti-inflammatory

Science

Mechanism of Action

The MONASCUS/ANGELICA KEISKEI LEAF/SOYBEAN FERMENT FILTRATE acts through a sophisticated, dual-mechanism approach. Monascus fermentation of soybeans significantly elevates levels of bioavailable aglycone isoflavones and coenzyme Q10 (CoQ10), potent antioxidants that neutralize free radicals and mitigate oxidative stress. This fermented complex precisely inhibits key enzymes responsible for skin degradation: tyrosinase, which reduces melanin production, and elastase, preserving skin elasticity. Furthermore, it directly curtails α-melanocyte stimulating hormone (α-MSH)-induced melanogenesis. Angelica keiskei extract complements this action, rich in protective flavonoids, offering additional antioxidant and anti-inflammatory benefits. It supports cellular regeneration, contributing to a more even skin tone and refined texture, and may also inhibit α-MSH pathways for enhanced melanin reduction.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In *in vitro* studies, Monascus-fermented soybean extracts (MFSEs) demonstrated superior inhibition of α-melanocyte stimulating hormone (α-MSH)-induced melanogenesis in B16F10 cells compared to arbutin, at concentrations up to 50 mg/mL. These MFSEs also exhibited stronger antioxidant, tyrosinase, and elastase inhibitory activities than unfermented soybean extracts.
  2. 02 Monascus-fermented soybean extracts consistently showed increased antioxidant capacities in *in vitro* tests, with efficacy directly correlating to concentrations ranging from 0.5 mg/mL to 50 mg/mL.
  3. 03 An 8% cream containing Angelica keiskei leaf extract effectively reduced melanin increase in ultraviolet B-exposed guinea pig skin, demonstrating comparable efficacy to a 4% hydroquinone cream. This *in vivo* model also showed inhibition of tyrosinase enzyme activity, though to a lesser extent than 4% hydroquinone.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Monascus-fermented soybeans exhibit enhanced solubility in acidic pH ranges compared to unfermented counterparts, with decreased solubility at neutral to alkaline pH (7-9), indicating a pH-sensitive solubility profile. Angelica keiskei leaf extract has shown physical stability when formulated within a serum gel for up to 28 days.

Synergies

  • Antioxidants
  • Tyrosinase Inhibitors
  • Elastase Inhibitors
  • Cellular Regenerators

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The specific combined ingredient, MONASCUS/ANGELICA KEISKEI LEAF/SOYBEAN FERMENT FILTRATE, has not undergone individual safety reviews by CIR, SCCS, or FDA for cosmetic applications. While CIR has reviewed certain yeast-derived ingredients with varied conclusions (often citing insufficient data), soybean is Generally Recognized As Safe (GRAS) by the FDA for food use. Angelica keiskei has a long history of traditional use as a medicinal plant and health food.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This ingredient offers a compelling range of benefits from antioxidant protection to significant anti-aging and brightening effects, validated by robust *in vitro* and *in vivo* animal studies on its components, though further human clinical data for the combined filtrate would solidify its full potential.

Related

Similar Ingredients

Finding similar ingredients…