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Moumoujus

MONARDA FISTULOSA.

Insufficient Data CAS 97952-61-9 / SKIN CONDITIONING

Monarda fistulosa, also known as Wild Bergamot or Bee Balm, is a botanical extract with recognized antimicrobial, anti-inflammatory, and antioxidant properties. Its active constituents, such as thymol and carvacrol, contribute to its potential benefits for blemish-prone and sensitive skin types.

Summary

Antimicrobial Anti-inflammatory Antioxidant Antiseborrheic

Science

Mechanism of Action

Monarda fistulosa operates through several pathways on the skin. Key components like thymol and carvacrol possess antibacterial, antimycotic, and antifungal effects by disrupting bacterial plasma membranes, leading to cell leakage and death. Extracts also demonstrate anti-inflammatory action by reducing lipopolysaccharide-induced interleukin-6 cytokine production in macrophages. Additionally, its essential oils activate Transient Receptor Potential A1 (TRPA1) ion channels and exhibit antioxidant capabilities through DPPH radical scavenging, collectively suggesting antiseborrheic potential.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A 0.5% Monarda fistulosa hydrolate (containing 0.0022% thymol) displayed strong antimicrobial activity against E. larvarum eggs.
  2. 02 A methanolic flower crude extract decreased lipopolysaccharide-induced interleukin-6 cytokine production by RAW 264.7 macrophages.

Transparency

Dusting Analysis

Not commonly dusted

Based on its specific mechanism of action and intended benefits, Monarda fistulosa is not typically used as an inactive filler ingredient.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Solubility is extract-dependent; essential oils are generally oil-soluble, while hydrolates and infusions typically demonstrate water solubility for certain components.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not yet reviewed Monarda fistulosa for topical applications. While an acute oral toxicity study in rats showed no adverse effects at doses up to 5,000 mg/kg, this data does not directly translate to comprehensive topical cosmetic safety assessments. It is not explicitly regulated by the FDA for cosmetic product claims related to a hydrosol.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Low

Our Assessment

Verdict

Insufficient Data

Monarda fistulosa shows promising antimicrobial, anti-inflammatory, and antioxidant properties in vitro, but requires further comprehensive human topical clinical studies and a CIR safety review to establish optimal concentrations and broad efficacy.

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