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Moumoujus

MOMORDICA GROSVENORII FRUIT EXTRACT.

Valuable CAS - / ANTIOXIDANT

Momordica Grosvenorii Fruit Extract, derived from the monk fruit, is a potent botanical ingredient distinguished by its robust antioxidant and anti-inflammatory capabilities. It also demonstrates anti-glycation activity, actively contributing to maintaining cellular integrity and protecting skin from environmental aggressors.

Summary

Antioxidant Humectant Soothing Anti-inflammatory Anti-glycation

Science

Mechanism of Action

This extract functions as a multi-pronged protector, primarily through its mogroside content. It actively combats oxidative stress by scavenging free radicals, reducing reactive oxygen species (ROS), and decreasing malondialdehyde (MDA) content. Simultaneously, it enhances the activity of crucial endogenous antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in skin fibroblasts. Beyond its antioxidant role, it exhibits direct anti-inflammatory effects and effectively inhibits BSA glycation, a process linked to skin aging.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies observed significant inhibition of BSA glycation at concentrations of 125 μg/mL and 500 μg/mL, with the higher concentration demonstrating efficacy comparable to aminoguanidine.
  2. 02 Mogroside V was shown to augment the anti-oxidative stress capacity of skin fibroblasts by decreasing ROS and MDA levels, while simultaneously elevating the activities of SOD, GSH-Px, and CAT in an in vitro model exposed to H2O2.
  3. 03 Animal studies indicated inhibitory effects on inflammation and tumor promotion induced by 12-O-tetradecanoylphorbol 13-acetate in mouse skin.
  4. 04 Demonstrated anti-inflammatory activities in murine macrophages and in a murine ear edema model.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

A commercially available product containing 7% Mogroside V has a reported pH of 8.0 ± 0.5. The cultivation of the Momordica Grosvenorii plant naturally thrives in a soil pH range of 4.0-6.5, typically around 5.5, suggesting a preference for slightly acidic conditions in its natural habitat.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The U.S. FDA has granted 'Generally Recognized As Safe' (GRAS) status for Momordica Grosvenorii Fruit Extract for use in foods. In the EU, it is authorized in cosmetics as a humectant, solvent, and antioxidant according to the CosIng database. While animal studies suggest mogrosides are essentially non-toxic at high oral doses, the European Food Safety Authority (EFSA) Panel for food additives concluded the toxicity database was insufficient for food additive safety, citing concerns regarding genotoxic potential of metabolites and observed testicular effects in a 90-day rat study, which were not dismissed. These EFSA concerns specifically pertain to oral ingestion as a food additive and may not directly translate to topical cosmetic application safety.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Momordica Grosvenorii Fruit Extract is a valuable ingredient, providing multifaceted benefits including robust antioxidant, anti-inflammatory, and anti-glycation properties to support skin health and resilience.

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