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MIXED ISOPROPANOLAMINES LAURYL SULFATE.

Questionable CAS - / CLEANSING, SURFACTANT - CLEANSING

Mixed Isopropanolamines Lauryl Sulfate is an anionic surfactant primarily utilized for its robust cleansing, foaming, and emulsifying capabilities in cosmetic formulations. Functionally similar to other lauryl sulfates, it is recognized for its potential to interact with and disrupt the skin's protective barrier.

Summary

cleansing surfactant foaming emulsifying

Science

Mechanism of Action

As an anionic surfactant, Mixed Isopropanolamines Lauryl Sulfate reduces surface tension, facilitating effective cleansing and emulsification. On the skin, it can interfere with the lipids and proteins within the stratum corneum, potentially compromising the skin barrier function. This disruption may lead to increased transepidermal water loss (TEWL) and can also enhance the penetration of other active materials into the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A patch test of 0.5% Sodium Lauryl Sulfate (SLS) on 1600 participants resulted in 41.8% experiencing irritation (e.g., redness, itch, scale) after two days.
  2. 02 For general lauryl sulfates like SLS, a 1% concentration can repeatedly cause irritant contact dermatitis when left on the skin for 16 hours a day for over three days. For facial cleansers, a recommended maximum SLS concentration is around 1% depending on individual sensitivity.
  3. 03 Sodium Lauryl Sulfate (SLS) and Ammonium Lauryl Sulfate (ALS) are identified as irritants in patch testing at concentrations of 2% and higher, with irritation severity increasing with concentration.

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
1%

Mixed Isopropanolamines Lauryl Sulfate is a primary surfactant, not typically 'dusted'. However, for products intended for prolonged skin contact, concentrations exceeding 1% are identified as a potential red flag due to increased irritation risk, based on analogous lauryl sulfates.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for stability was found for Mixed Isopropanolamines Lauryl Sulfate. For Sodium Lauryl Sulfate (SLS), a 1% aqueous solution typically exhibits a pH range of 7.0 to 9.5, tending towards alkalinity when diluted in water.

Conflicts

  • N-nitrosating agents (due to the isopropanolamine component)
  • Alkaline drugs (can form poorly soluble lauryl sulfate salts)

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
1%
Sensitization risk Low

The CIR Expert Panel considers the 'Isopropanolamine' and 'Mixed Isopropanolamines' components safe, provided they are not used with N-nitrosating agents. For the lauryl sulfate portion, data on Sodium Lauryl Sulfate indicates it is safe but a recognized irritant at concentrations of 2% and greater. For products intended for prolonged skin contact, concentrations should not exceed 1% to mitigate irritation risk.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While effective as a cleansing and foaming agent, its propensity to disrupt the skin barrier and cause irritation, especially in leave-on applications or for sensitive skin, renders its inclusion questionable for precision skincare formulations.

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