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MIXED ISOPROPANOLAMINES.

Optional CAS - / BUFFERING

Mixed Isopropanolamines are a group of chemical compounds primarily utilized as pH adjusters in cosmetic and personal care formulations. This ingredient is crucial for maintaining the precise pH balance of products, which supports the stability and optimal performance of other active ingredients.

Summary

pH adjuster Buffering agent

Science

Mechanism of Action

Functioning as a buffering agent, Mixed Isopropanolamines are adept at controlling and stabilizing the pH levels within a formulation. By neutralizing acidic components, they help to sustain a consistent and desirable pH environment, which is vital for product integrity and efficacy.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical studies conducted by the CIR Safety Review indicated that individual components, such as Diisopropanolamine at 1% and Triisopropanolamine at 1.1%, were associated with minimal skin irritation and contact sensitization.
  2. 02 Further human studies demonstrated that Diisopropanolamine and Isopropanolamine, when applied at concentrations of 2%, did not induce allergic contact dermatitis or photoallergic dermatitis.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Mixed Isopropanolamines are typically clear, colorless liquids that maintain stability under normal storage conditions. However, they are highly reactive with acids, readily forming corresponding amine salts.

Conflicts

  • N-nitrosating agents (due to the potential formation of harmful nitrosoamines)
  • Acids (rapidly reacts to form amine salts, potentially altering intended function)

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
1%
Sensitization risk Low

The CIR Expert Panel has concluded that Mixed Isopropanolamines and their constituent components are safe for use in cosmetics at concentrations similar to those evaluated, with a maximum recommended concentration of 1%. A critical restriction is that these ingredients must not be used in formulations containing N-nitrosating agents to prevent the formation of nitrosoamines. Furthermore, it is important to note that Diisopropanolamine, a component frequently associated with Mixed Isopropanolamines, is prohibited in cosmetic products marketed in Europe as per Annex II of the Cosmetics Directive.

Your Skin

Skin Compatibility

Yes Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Mixed Isopropanolamines serve as an effective pH adjuster, considered safe for cosmetic use up to 1% when strictly avoiding N-nitrosating agents, though one common component, Diisopropanolamine, is banned in the EU market.

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