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Moumoujus

MIPA-BORATE.

Avoid CAS 26038-90-4; 68003-13-4 / BUFFERING

MIPA-BORATE functions as a precision pH-buffering agent, stabilizing cosmetic formulations to optimize active ingredient efficacy and prevent potential skin irritation. However, its confirmed breakdown into boric acid, a classified CMR 1B substance, has led to its prohibition within EU cosmetic products.

Summary

buffering viscosity controlling

Science

Mechanism of Action

MIPA-BORATE operates by maintaining the pH equilibrium within a cosmetic formulation. This precise pH control is fundamental for ensuring the stability and optimal efficacy of other active components, simultaneously preventing potential skin irritation that can arise from pH fluctuations.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

MIPA-BORATE is a water-soluble ingredient engineered to stabilize formulation pH. A critical consideration, however, is its propensity to break down into boric acid upon contact with water, which carries significant regulatory implications, particularly its prohibition in EU cosmetics due to boric acid's CMR 1B classification.

Conflicts

  • Water (due to decomposition into boric acid)
  • Formulations designated for use on infant skin or compromised skin barriers
  • Cosmetic products intended for the EU market (due to regulatory prohibition)

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
5%
Pregnancy
Caution
Sensitization risk Unknown

The CIR Expert Panel has deemed MIPA-BORATE safe for cosmetic use at concentrations up to 5%, provided the final formulation is non-irritating and not intended for infant or injured skin. However, the SCCS has concluded that MIPA-BORATE hydrolyzes into boric acid upon contact with water. Boric acid is classified as a Carcinogenic, Mutagenic, or Reprotoxic (CMR) Category 1B substance, leading to MIPA-BORATE's prohibition in cosmetic products under EU Cosmetics Regulation. The FDA does not pre-approve cosmetic ingredients for market; while some related borates are approved as indirect food additives with limitations, there is no direct FDA approval for MIPA-BORATE in cosmetic applications. Given the CMR 1B classification of its breakdown product, boric acid, its use during pregnancy is contraindicated.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Low

Our Assessment

Verdict

Avoid

Despite its buffering capabilities, MIPA-BORATE is prohibited in EU cosmetics due to its breakdown into boric acid, a classified CMR 1B substance, making its inclusion in precision skincare formulations highly problematic and inadvisable.

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