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MILKAMIDOPROPYL AMINE OXIDE.

Valuable CAS 188550-51-8 / HAIR CONDITIONING

Milkamidopropyl Amine Oxide, often referred to as Cocamidopropylamine Oxide, is an amphoteric surfactant that effectively cleanses the skin and enhances foam generation. It also serves as a conditioning agent, contributing to the mildness and stability of formulations.

Summary

Cleansing Foam Boosting Hair Conditioning Hydrotrope Surfactant

Science

Mechanism of Action

This ingredient reduces surface tension, a key characteristic of amphoteric surfactants, enabling it to efficiently emulsify and remove oil and dirt during cleansing. It functions as a robust foam booster, improves product stability, and offers conditioning benefits. Its behavior is pH-dependent, exhibiting non-ionic properties in neutral/alkaline environments and cationic properties in acidic conditions.

Research

Clinical Evidence

High confidence
Effective range 0.07–4%
Optimal

N/A

Key findings

  1. 01 Demonstrated safety for use in cosmetic and personal care rinse-off formulations at concentrations ranging from 0.07% to 4.0%.
  2. 02 Evaluations at 5% concentration indicated it is not a primary dermal irritant.
  3. 03 At 7.5%, it was found not to be a sensitizer, although some reactions typical of mild irritation were observed.
  4. 04 A high concentration of 81.5% was shown to induce moderate dermal irritation in rabbit skin and severe eye irritation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 7
0 7 14

Stability

Exhibits excellent stability and compatibility across a broad pH range, from acidic to alkaline, although its functionality (e.g., foam boosting, thickening) can be influenced by pH. It is compatible with anionic, cationic, amphoteric, and non-ionic surfactants, as well as various cosmetic raw materials. Prolonged heating above 100°C should be avoided.

Synergies

  • Anionic surfactants
  • Cationic surfactants
  • Amphoteric surfactants
  • Non-ionic surfactants
  • Various dye raw materials
  • Various cosmetic raw materials

Conflicts

  • Prolonged heating above 100°C

Safety

Safety Profile

CIR Status
Safe as used
Max tested
4%
Pregnancy
Safe
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel deemed it safe for use in rinse-off products up to 4.0%. It demonstrates low toxicity in animal and in vitro tests, with no indication of carcinogenic potential and no evidence of reproductive or developmental toxicities. Dermal absorption is slow. While very high concentrations (e.g., 81.5%) can cause irritation, it is considered gentle at common cosmetic use concentrations. However, manufacturing impurities such as amidoamines and dimethylaminopropylamine (DMAPA) are known skin irritants.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Milkamidopropyl Amine Oxide is a valuable, gentle amphoteric surfactant, adept at cleansing and foam boosting, suitable for all skin types in rinse-off formulations at concentrations up to 4.0%.

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