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Moumoujus

MIBK.

Avoid CAS 108-10-1 / DENATURANT, PERFUMING, SOLVENT

MIBK, or Methyl Isobutyl Ketone, is an aliphatic ketone primarily recognized for its solvent and alcohol denaturant properties in cosmetic formulations. While effective in these roles, its direct or prolonged contact with skin can induce drying and flaking, making it unsuitable for enhancing skin health.

Summary

Solvent Denaturant Perfuming Agent

Science

Mechanism of Action

Functioning as an aliphatic ketone, MIBK efficiently dissolves other substances and serves to denature alcohol in various cosmetic products. On the skin, its action can disrupt the natural moisture balance, leading to dehydration and subsequent flaking with repeated or extended exposure.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Conflicts

  • Can cause drying and flaking of the skin with prolonged or repeated contact.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
21%
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel concluded MIBK is safe when used in nail polish removers and as an alcohol denaturant, a decision reaffirmed in March 2024. The highest reported concentration of use is 21% in nail correction pens. The FDA includes MIBK on its list of direct and indirect food additives for flavoring. Studies in rats showed reduced hair follicle mitotic activity and increased epidermal thickness at dermal applications of 300-600 mg/kg, and ocular irritation was noted in humans exposed to 200 ppm in air.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its high irritancy, potential for skin drying and flaking, and primary functions as a solvent and denaturant without direct skin benefits, MIBK is not recommended for precision skincare formulations.

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