Science
Mechanism of Action
The precise mechanism of Methylvaleric Acid's action on skin is not detailed in the available research.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Methylvaleric acid isomers display acidic characteristics, with pKa values of 4.782 for 2-Methylvaleric acid and 4.766 for 3-Methylvaleric acid (both at 25°C). Solubility varies by isomer: 2-Methylvaleric acid shows solubility in water (13g/L) and 95% alcohol (1ml in 1ml), while 3-Methylvaleric acid is reported as insoluble in water but soluble in alcohol. 4-Methylvaleric acid has conflicting water solubility data but is noted as soluble in alcohol.
Safety
Safety Profile
Methylvaleric acid, particularly 2-methylvaleric acid, is classified as a corrosive substance (Skin Corr. 1B, H314; Eye Dam. 1, H318). It is documented to cause burns and irritation upon contact with skin and eyes, indicating a high potential for adverse reactions. Although certain isomers are FDA-listed as food flavoring agents (e.g., FEMA 2754, FEMA 3437), there is no specific FDA status or dedicated safety assessment for its application as a cosmetic ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given its classification as a corrosive substance with high potential for causing skin burns and severe irritation, Methylvaleric Acid is definitively not recommended for any cosmetic applications.
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References
Sources