Science
Mechanism of Action
This ingredient operates by chemically disrupting the disulfide bonds found within the keratin protein structure of hair. This molecular alteration allows for hair fibers to be easily reshaped during waving or straightening processes, or efficiently removed in depilatory formulations.
Research
Clinical Evidence
High confidence8%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Methyl Thioglycolate has a pKa of 8.08. Its parent compound, Thioglycolic Acid, is prone to oxidation upon exposure to air and exhibits superior stability when stored in glass containers compared to polyolefin bottles.
Conflicts
- strong bases
- heat, sparks, open flames, and other ignition sources (flammable liquid and vapor)
Safety
Safety Profile
The CIR Expert Panel determined Methyl Thioglycolate is safe for use in specified hair products up to 15.2% (as Thioglycolic Acid equivalent), but critically advises hairdressers to avoid skin contact and minimize consumer exposure. The parent compound, Thioglycolic Acid, is classified as a severe skin and eye irritant (Skin Corr. 1B; H314), capable of causing severe skin burns and eye damage. Use is strictly regulated by concentration and pH.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its potent hair-modifying action and the significant risk of severe skin irritation and burns associated with its use, Methyl Thioglycolate is not suitable for general skincare formulations and should be avoided in products intended for direct skin application.
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References
Sources