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Moumoujus

METHYL NONYLENATE.

Avoid CAS 111-79-5 / PERFUMING

Methyl Nonylenate is a synthetic fragrance compound primarily employed for its distinct fruity, green, and citrusy aroma in various personal care and cosmetic formulations. Despite its pleasant scent, its chemical structure presents a significant risk of skin sensitization, leading to stringent regulatory restrictions on its use.

Summary

Perfuming

Science

Mechanism of Action

This unsaturated ester, also known as Methyl 2-nonenoate, functions exclusively as a fragrance. Its chemical profile includes an electrophilic α,β-unsaturated ester group, which possesses the inherent ability to react with proteins in the skin. This reactivity is identified as the core mechanism responsible for its potential to induce local skin sensitization.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Methyl Nonylenate is utilized as a fragrance ingredient, not as an active compound with a dose-dependent therapeutic effect. Its inclusion in formulations is strictly limited by regulatory safety thresholds to mitigate sensitization risks, rather than to achieve a specific skin benefit. Therefore, the concept of 'dusting' for sub-efficacious active concentrations is not applicable.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

For optimal stability and to prevent degradation, Methyl Nonylenate should be stored in a cool, dry, and dark environment, meticulously protected from exposure to oxidizing agents.

Conflicts

  • Oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.002%
Sensitization risk High

The European Scientific Committee on Consumer Safety (SCCS) has imposed strict limitations on Methyl Nonylenate (Methyl 2-nonynoate) in cosmetic products due to its high potential for local skin sensitization, classifying it as a critical health effect. Its maximum allowable concentration in finished products is 0.002% when used alone. If formulated in combination with methyl 2-octynoate, the total concentration must not exceed 0.01%, with Methyl Nonylenate still limited to 0.002%. A specific Cosmetic Ingredient Review (CIR) assessment for Methyl Nonylenate has not been identified.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Methyl Nonylenate is classified as 'avoid' for precision skincare formulations due to its high inherent risk of skin sensitization, evidenced by stringent regulatory restrictions, and its lack of any recognized dermatological benefits.

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