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METHYL-METHYLENE-OCTADIENE ALPHA-TERPINEOLS.

Avoid CAS 72869-31-9 / PERFUMING

METHYL-METHYLENE-OCTADIENE ALPHA-TERPINEOLS is a technical grade alpha-terpineol derivative known for its capacity to enhance the skin's absorption of other active ingredients. It also provides antioxidant and anti-inflammatory effects, contributing to overall skin health.

Summary

Fragrance Solvent Masking Penetration Enhancer Antioxidant Anti-inflammatory Antimicrobial

Science

Mechanism of Action

This ingredient operates on multiple fronts: it enhances the transdermal delivery of other active compounds by disrupting the stratum corneum's intracellular lipid bilayers and forming polar pathways, thereby increasing their thermodynamic activity. Additionally, it exhibits antioxidant and anti-inflammatory properties, contributing to the reduction of skin redness and supporting a healthier skin environment.

Research

Clinical Evidence

Medium confidence
Effective range 2.5–5%
Optimal

5%

Key findings

  1. 01 At 2.5%, it enhanced transdermal delivery of lidocaine by forming eutectic mixtures and increasing thermodynamic activity.
  2. 02 Pre-treatment of rat skin with 5% alpha-terpineol in an ethanolic solution for 1 hour enhanced curcumin permeation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Alpha-terpineol remains stable when stored in cool, dry, well-ventilated areas, away from direct sunlight, in tightly sealed containers, ideally below 25°C (77°F) or 2-8°C. It demonstrates good alkali resistance. Degradation rates vary by formulation medium, with creams showing faster degradation than gels or solutions. Oxidation must be minimized due to the sensitizing potential of oxidized forms.

Conflicts

  • strong oxidizers

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
5%
Sensitization risk Moderate

Safety data specifically for METHYL-METHYLENE-OCTADIENE ALPHA-TERPINEOLS (CAS 72869-31-9), identified as alpha-terpineol fractions, is limited. Therefore, assessments are primarily based on Alpha-Terpineol (CAS 98-55-5), which is FDA-approved as a food additive and EPA-approved in pesticide formulations up to 5%, deemed safe for the general population. However, the SCCS lists alpha-terpineol as an 'Established Contact Allergen in Humans' with a low level of importance. The CIR Expert Panel concluded that botanical ingredients containing alpha-terpineol are safe in cosmetics when formulated to be non-sensitizing and non-irritating, emphasizing that oxidized forms can be sensitizers. Therefore, precise formulation to prevent oxidation is crucial.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

While offering significant benefits as a penetration enhancer and for its antioxidant and anti-inflammatory properties, its classification as a contact allergen and moderate irritancy risk, particularly from oxidized forms, warrants its avoidance in formulations where minimizing sensitization potential is paramount.

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