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Moumoujus

METHYL ISOEUGENOL.

Questionable CAS 93-16-3 / PERFUMING

Methyl Isoeugenol is a synthetic aromatic compound widely utilized as a fragrance ingredient within the cosmetic industry. While primarily valued for its olfactory contributions, research on related compounds suggests potential biochemical activities on the skin, although direct clinical evidence for these benefits is currently absent.

Summary

Fragrance ingredient Antioxidant (potential) Anti-inflammatory (potential)

Science

Mechanism of Action

Based on studies involving structurally related compounds such as methyl eugenol and isoeugenol, Methyl Isoeugenol theoretically possesses the capacity to activate the Nrf2 signaling pathway, which is associated with contributing to an antioxidant response. Additionally, it may exert anti-inflammatory effects through the modulation of NF-κB and MAPK signaling pathways.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Methyl Isoeugenol is susceptible to discoloration, specifically turning red, when exposed to light and alkaline conditions. For optimal stability, it must be stored in tightly sealed containers in a cool, dry environment, protected from both heat and light. Its use is not recommended in formulations with alkaline bases, such as many shower gels or shampoos.

Conflicts

  • Alkaline bases
  • Light
  • Heat
  • Sources of ignition

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Moderate

Methyl Isoeugenol is classified as a 'rare sensitizer' and carries the hazard statement 'H317 - May cause an allergic skin reaction'. Acute dermal toxicity studies in rabbits indicate a low acute toxicity, with an LD50 exceeding 5 g/kg. While the CIR deems it safe with restrictions, specific maximum concentrations for cosmetic use are not explicitly defined by this body. Observational data shows it is present in some products in concentrations ranging from 64.9 ppm (0.00649%) to 1755.0 ppm (0.1755%). For a structurally related compound, isoeugenol, the International Fragrance Association (IFRA) recommends concentrations below 200 ppm (0.02%) due to its sensitizing potential, highlighting a general caution for this chemical class.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Primarily a fragrance ingredient with theoretical but unproven skin benefits, Methyl Isoeugenol carries a moderate risk of allergic sensitization, making its inclusion in precision skincare formulations questionable despite its 'safe with restrictions' status.

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