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METHYL ETHYLACETOACETATE.

Insufficient Data CAS 51756-08-2 / PERFUMING

Methyl Ethylacetoacetate is primarily incorporated into cosmetic formulations as a perfuming agent, contributing an aromatic component to the product. Currently, specific safety evaluations for its use in skincare are not available, and it has no identified direct benefits for skin health.

Fragrance Ingredient

Science

No specific mechanism of action on the skin has been identified or described for Methyl Ethylacetoacetate in the available research. Its primary utility is confined to its olfactory properties.


Research

Insufficient-data confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Methyl Ethylacetoacetate is soluble in alcohol. Although some reports indicate insolubility in water, an estimated water solubility of 5.276e+004 mg/L (52.76 g/L) at 25 °C suggests significant aqueous dispersibility. For optimal stability in formulations, maintaining a neutral pH range is advisable, as related acetoacetate compounds exhibit instability in the presence of strong aqueous acids or bases.

Conflicts

  • Strong aqueous acids
  • Strong aqueous bases
  • Oxidizing materials

Safety

CIR Status
Not reviewed
Sensitization risk Unknown

Methyl Ethylacetoacetate (CAS 51756-08-2) has not undergone specific safety assessments by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) for cosmetic use. However, related compounds, Methyl acetoacetate (CAS 105-45-3) and Ethyl acetoacetate (CAS 141-97-9), are approved by the FDA as food flavoring agents. These related substances demonstrate low animal toxicity, with Ethyl acetoacetate reporting an oral LD50 of 3.98 g/kg in rats and generally noted to be less irritating to skin and eyes than its methyl ester counterpart.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

With its primary identified role as a fragrance agent and a lack of specific cosmetic safety assessments or demonstrated skin benefits, further data is required to determine its value in precision skincare.


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