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Moumoujus

METHYL BIMATOPROST ACIDATE.

Avoid CAS 38315-47-8 / HAIR CONDITIONING

Methyl Bimatoprost Acidate is a synthetic prostamide F2α analog recognized for its potent ability to stimulate hair growth. It effectively enhances the length, thickness, and darkness of hair, specifically targeting eyelashes and eyebrows by influencing the hair growth cycle.

Summary

Hair Conditioning

Science

Mechanism of Action

This ingredient functions by binding to specific prostaglandin receptors present in hair follicles. This interaction extends the anagen (growth) phase of the hair cycle and promotes the enlargement of the dermal papilla, resulting in the development of longer and thicker hair. Additionally, it stimulates melanogenesis, contributing to increased hair pigmentation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.03%

Transparency

Dusting Analysis

Not commonly dusted

Methyl Bimatoprost Acidate is a pharmacologically active substance, not a cosmetic elegance ingredient, and its efficacy is concentration-dependent, making 'dusting' inappropriate.

The Formula

Formulation

Solubility
Both
Optimal pH 6.8 – 7.8
0 7 14

Stability

The parent compound, Bimatoprost, exhibits high solubility in ethyl and methyl alcohols, with slight solubility in water. Ophthalmic solutions containing Bimatoprost typically maintain stability within a pH range of 6.8-7.8 during shelf life, with some formulations specifying a pH of 7.3 ± 0.5. Certain Bimatoprost acid polymorphs can transition into an oil phase at temperatures above 22°C in nitromethane or 40°C in anisole.

Conflicts

  • Contact lenses (should be removed before application and reinserted after 15 minutes to avoid absorption into lenses)
  • Other topical ophthalmic agents (administration should be separated by at least 5 minutes)
  • Benzalkonium chloride hypersensitivity (as it is a common preservative in formulations)
  • Unintended skin contact (may induce undesired hair growth)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Although listed in the European Commission's CosIng database as a hair conditioning agent, the Scientific Committee on Consumer Safety (SCCS) has raised substantial concerns regarding the safety of prostaglandin analogues, including Methyl Bimatoprost Acidate, when used in cosmetic products, particularly around the eyes. These compounds are potent pharmacologically active substances with the potential for effects even at very low concentrations. Several regulatory authorities have either advised against or prohibited their use in eyelash growth-promoting cosmetics. The CIR Expert Panel has acknowledged Methyl Bimatoprost Acidate in discussions concerning the review of prostaglandin analogues, noting that similar compounds like Bimatoprost are US FDA-approved prescription drugs (e.g., Latisse 0.03% ophthalmic solution) for eyelash hypotrichosis. Reported side effects associated with Bimatoprost include conjunctival hyperemia (eye redness), eye pruritus (itching), periocular skin hyperpigmentation, eye irritation, dry eye, eyelid erythema, and the potential for permanent darkening of the iris.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its demonstrated efficacy in promoting hair growth, Methyl Bimatoprost Acidate presents significant safety concerns and regulatory warnings, rendering its inclusion in cosmetic products highly discouraged due to the risk of adverse effects.

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