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Moumoujus

METHYL 2-OCTYNOATE.

Avoid CAS 111-12-6 / PERFUMING

Methyl 2-octynoate is a synthetic fragrance compound primarily utilized for its distinct fruity-floral aroma. Despite its aromatic properties, it is classified as an established contact allergen, demanding stringent concentration limits and labeling requirements in cosmetic formulations due to its potential to induce skin sensitization.

Summary

perfuming fragrance enhancer

Science

Mechanism of Action

This ingredient functions primarily as a fragrance enhancer, contributing a fruity and floral scent profile to formulations. Chemically, it is an α,β-unsaturated ester, possessing an electrophilic group that is capable of reacting with dermal proteins, a mechanism believed to underpin its capacity for skin sensitization.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A Human Repeat Insult Patch Test (HRIPT) conducted on 104 volunteers, using methyl 2-octynoate at a concentration of 118 μg/cm², observed no reactions indicative of skin sensitization.
  2. 02 In contrast, routine patch testing studies involving 7257 patients demonstrated positive reactions to 1% methyl 2-octynoate in petrolatum in 0.1–0.2% of individuals, indicating its potential as a sensitizer at higher concentrations.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.001%
Red flag below
1%

Methyl 2-octynoate is commonly 'dusted' from precision skincare formulations due to its classification as an established contact allergen. The EU mandates labeling when concentrations exceed 0.001% in leave-on products, and patch tests show a red-flag sensitization rate at 1% of the ingredient, making its inclusion at any functional level for fragrance a significant risk for sensitive individuals.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Methyl 2-octynoate demonstrates general stability and compatibility across various solvents. No specific optimal pH range for its stability has been determined from available research.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.01%
Sensitization risk High

The Scientific Committee on Consumer Safety (SCCS) identifies methyl 2-octynoate as an established contact allergen, necessitating strict regulation. Its concentration in cosmetic products must not exceed 0.01% when used as a sole fragrance ingredient. It is listed in Annex III of EU Regulation (EC) No. 1223/2009, signifying restricted use. Products exceeding 0.001% in leave-on and 0.01% in rinse-off formulations require specific labeling in the EU. While the Research Institute for Fragrance Materials (RIFM) considers it safe within prescribed dosages and the FDA approves it as a flavoring agent in food, its established allergen profile remains a primary safety concern for topical skincare application.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as an established contact allergen and high sensitization risk, methyl 2-octynoate is not recommended for inclusion in precision skincare formulations.

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