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METHYL 2,6,10-TRIMETHYLCYCLODODECA-2,5,9-TRIENYL KETONE.

Questionable CAS 28371-99-5 / PERFUMING

This synthetic compound functions primarily as a perfuming agent, lending rich woody, ambergris, musk, vetiver, and tobacco notes to product formulations. It does not contribute direct therapeutic benefits to the skin.

Perfuming agent

Science

Methyl 2,6,10-trimethylcyclododeca-2,5,9-trienyl ketone operates exclusively as a fragrance ingredient, designed to impart specific aromatic characteristics. There is no identified mechanism through which it exerts direct dermatological effects or benefits.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The ingredient demonstrates notable stability across a diverse array of product chemistries, including acidic cleaners, alcoholic lotions, deodorants, detergents, various soaps, and shampoos.


Safety

CIR Status
Safe with restrictions
Max tested
0.52%
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated this ingredient and determined it safe for use under specific concentration restrictions. The International Fragrance Association (IFRA) imposes strict limits due to documented concerns regarding dermal sensitization and potential systemic toxicity. For products like face moisturizers (IFRA Category 5B), the maximum permissible concentration is 0.52%. The Environmental Working Group (EWG) assesses its risk for allergies and immunotoxicity as 'MODERATE', while other toxicity concerns (cancer, developmental, reproductive) are rated 'LOW'.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Questionable

Given its sole function as a fragrance agent, absence of direct skincare benefits, and documented moderate risk for dermal sensitization requiring strict concentration limits, its inclusion in precision skincare formulations is questionable.


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