Science
Mechanism of Action
This compound is swiftly absorbed through the skin. Internally, it is metabolized by the enzyme alcohol dehydrogenase into methoxyacetic acid, which is the direct cause of its toxic properties and broad systemic impact.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Methoxyethanol is generally stable under recommended storage conditions; however, exposure to air and light can lead to the formation of potentially explosive peroxides.
Conflicts
- strong oxidizing agents
- oxygen (forms peroxides)
- acid chlorides
- acid anhydrides
- strong bases (may cause decomposition)
- some forms of plastics, rubber, and coatings (may attack them)
Safety
Safety Profile
The SCCNFP, a precursor to the SCCS, concluded that 2-methoxyethanol poses a significant health risk in cosmetic products and classified it as a Category 2 reproductive toxin. It is readily absorbed through the skin and has been associated with severe haematological, neurological, and reproductive toxic effects in both human and animal studies. Norway has prohibited its use in cosmetics, and it is listed on California Proposition 65 due to its potential for reproductive and developmental toxicity. Exposure may lead to long-term nerve damage, kidney damage, damaged blood cells, and testicular damage, and it is considered a possible human teratogen.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Methoxyethanol is highly toxic, a known reproductive toxin, and banned in cosmetics in some regions; therefore, its use in skincare is strictly contraindicated and should be avoided.
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References
Sources