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METHOXY PEG/PPG-7/3 AMINOPROPYL DIMETHICONE.

Avoid CAS 298211-68-4 / HAIR CONDITIONING

Methoxy PEG/PPG-7/3 Aminopropyl Dimethicone is a self-emulsifying siloxane copolymer, engineered for conditioning due to its strong substantivity to protein surfaces. It is designed to impart a smooth feel and enhance stability within aqueous formulations.

Hair Conditioning Emulsifying

Science

This ingredient functions primarily as a conditioning agent by adsorbing strongly to protein structures found on both hair and skin surfaces. Its hydrophilic PEG/PPG groups facilitate excellent compatibility within aqueous systems, enabling it to act as a self-emulsifier. For hair, it improves combability and adds volume without heavy residue, while its affinity for skin proteins suggests a surface-modifying and conditioning action.


Research

Medium confidence
Effective range N/A
Optimal

0.5%

Key findings

  1. 01 A concentration of 0.50% was successfully incorporated into a conditioner for damaged hair, significantly contributing to its conditioning properties.
  2. 02 Noticeable conditioning and volumizing benefits in hair have been observed with the use of small quantities of this ingredient.

Transparency

Not commonly dusted

No specific data regarding 'dusting' (common issues from over-formulation or misuse leading to undesirable effects) for this ingredient were identified in the research.


The Formula

Solubility
Water
Optimal pH 3 – 7
0 7 14

Stability

The ingredient exhibits high compatibility with aqueous systems and possesses self-emulsifying properties. Optimal stability is generally found in acidic to slightly acidic pH ranges, typically between 3.0 and 7.0. Formulations may present instability, such as becoming grainy or chunky, during freeze/thaw cycles if precise ingredient ratios are not met within complex systems.

Conflicts

  • Potential for instability (granulation, chunkiness) during freeze/thaw cycles if specific ingredient ratios in complex formulations are not precisely maintained.

Safety

CIR Status
Insufficient data
Pregnancy
Caution
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel has issued an 'insufficient data' assessment for the broader class of polyoxyalkylene siloxane copolymers, requesting additional data on molecular weight ranges, impurities, dermal penetration, irritation, and sensitization for a complete safety evaluation. Of significant concern, the European Union Ecolabel program reports this substance as persistent in the environment and not anaerobically degradable. It is also suspected of damaging fertility, shows clear evidence of endocrine disruption in at least one animal study, and has the potential to cause genetic defects and cancer. It is classified as an allergen, can be irritating to the eyes, and in its raw solid or liquid form, may cause irritation to the skin, eyes, and respiratory system. While a general category of dimethicone-based compounds has been found non-comedogenic, this conclusion does not specifically apply to this particular molecule.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Avoid

Due to significant safety concerns, including suspected endocrine disruption, fertility damage, and genotoxicity, alongside an 'insufficient data' classification from CIR, this ingredient is not suitable for precision skincare formulations despite its conditioning and emulsifying properties.


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References