Science
Mechanism of Action
METHOXY PEG-7 DEHYDROCHOLESTERYL SUCCINATE operates as a potent Vitamin D analogue in the skin. Its primary mechanism involves promoting the healthy differentiation of epidermal cells and triggering the proliferation of new skin cells. This action is pivotal for re-establishing and fortifying the skin's barrier integrity, especially when compromised by inadequate Vitamin D levels. The compound's polyethylene glycol (PEG) component, conjugated with 7-Dehydrocholesterol (a pro-vitamin D), undergoes a PEGylation process to significantly increase its solubility in water, maximizing its biological effectiveness.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Conflicts
- Not permitted in organic or natural certified cosmetics due to concerns regarding ethoxylated substances and the use of ethylene oxide in its production.
Safety
Safety Profile
This ingredient has been designated 'Muy Dudoso' (Very Doubtful) by Sinaí Estética due to significant concerns related to ethoxylated substances and the potential for ethylene oxide, classified as a carcinogen, to be present from its manufacturing process. Further, it is cited in a California Proposition 65 Proposed Judgment, indicating its potential to cause cancer or reproductive toxicity. While many general PEG compounds are deemed safe when formulated to prevent irritation, the specific ethoxylation of this ingredient raises serious safety questions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its purported benefits for skin barrier support and cellular regeneration, this ingredient is associated with critical safety concerns, including potential carcinogenicity and reproductive toxicity, leading to its prohibition in certified natural and organic cosmetics.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources