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Moumoujus

METHOXY PEG-125 AMINE.

Valuable CAS 80506-64-5 / NOT REPORTED

Methoxy PEG-125 Amine is a polyethylene glycol derivative characterized by a hydrophilic methoxy end and a reactive amine group. While extensively utilized in bioconjugation applications, its PEG structure endows it with humectant properties for skin hydration. It can also enhance the solubility and penetration of other compounds in topical applications, serving as a functional ingredient.

Summary

Humectant Solubilizer Penetration Enhancer Skin Conditioning Agent

Science

Mechanism of Action

On skin, the polyethylene glycol chain of Methoxy PEG-125 Amine primarily functions as a humectant, attracting and retaining water to improve hydration and minimize transepidermal water loss. Its hydrophilic nature supports skin barrier integrity, and the PEG component can facilitate the enhanced penetration of other active ingredients. Additionally, it contributes to the solubilization of hydrophobic compounds within a formulation.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

This ingredient is sensitive to light and temperature, necessitating storage at low temperatures (2-8°C) under desiccated conditions and an inert gas atmosphere, while strictly avoiding repeated freeze-thaw cycles. The HCl salt form provides enhanced stability for the solid material. Primary amines are generally expected to be ionized around pH 7.0.

Conflicts

  • Oxidizing agents, particularly iron oxides, which can lead to oxidative degradation and the formation of formaldehyde and formic acid, potentially causing N-methylation and N-formylation.
  • Strong acids (unless in HCl salt form) or strong bases, due to the inherent reactivity of the amine group.
  • Activated carboxylic acids (e.g., NHS esters), aldehydes, and other amine-reactive functional groups, with which it will readily form covalent bonds.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Methoxy PEG-125 Amine has not undergone specific safety assessment by CIR or SCCS. However, the broader class of Polyethylene Glycols (PEGs) is generally considered safe for cosmetic use under intended conditions. It is important to note that PEGs can induce cross-sensitization in certain individuals, and pre-existing anti-PEG antibodies have been identified in the general population. Formulations should prioritize non-irritating profiles.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Methoxy PEG-125 Amine is valuable for its functional roles in formulation, acting as a solubilizer and penetration enhancer, and offering general humectant properties, though direct clinical efficacy data specifically for this molecule on skin benefits is limited.

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