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Moumoujus

METHIONYL SH-POLYPEPTIDE-7 SH-OLIGOPEPTIDE-1 SH-OLIGOPEPTIDE-2.

Questionable / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

This advanced peptide complex combines SH-Polypeptide-7, SH-Oligopeptide-1 (Epidermal Growth Factor, EGF), and SH-Oligopeptide-2 (Insulin-like Growth Factor 1, IGF-1) to function as a sophisticated cellular signaling mechanism. It stimulates innate repair pathways, promotes the regeneration of mature skin, and strengthens its structure, contributing to a visibly renewed complexion and reduction of wrinkles.

Summary

Cell-communicating ingredient Skin-restoring Wound healing Anti-aging Promotes cell proliferation and differentiation Strengthens skin barrier Improves skin texture and tone Reduces fine lines and wrinkles Boosts collagen and elastin production Increases hyaluronic acid (HA) production Anti-inflammatory Reduces hyperpigmentation and acne lesions Supports scalp rejuvenation and healthier hair growth

Science

Mechanism of Action

This ingredient functions as a complex of growth factor-mimicking peptides. SH-Oligopeptide-1 (EGF) acts as a cellular signal molecule, binding to the epidermal growth factor receptor (EGFR) to stimulate skin cell growth, proliferation, and differentiation of epithelial cells, ultimately strengthening the skin barrier, increasing hyaluronic acid production, and accelerating wound healing. SH-Oligopeptide-2 (IGF-1), a synthetic polypeptide hormone analog, enhances the regeneration of damaged cells by forming new blood vessels and activating the AKT cellular signaling pathway to mitigate aging processes. It synergistically promotes regeneration, accelerates wound healing, and boosts the biosynthesis of hyaluronic acid and other extracellular matrix components, which directly reduces the appearance of fine lines and wrinkles. SH-Polypeptide-7, a recombinant human peptide analogous to somatotropin (human growth hormone), further contributes to skin and scalp rejuvenation and healing. Collectively, these peptides activate endogenous repair mechanisms, stimulate the regeneration of mature skin, reinforce its structural integrity, and visibly diminish wrinkles.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Growth factors within peptide complexes are inherently challenging to maintain in active form. They typically require storage at very cold temperatures (e.g., -20°C) in laboratory environments. In cosmetic formulations, only an estimated 5-10% of growth factors may retain activity at room temperature. High heat or strong oxidizing agents are known to denature these peptides, significantly reducing their efficacy.

Synergies

  • SH-Oligopeptide-2 (IGF-1) works synergistically with SH-Oligopeptide-1 (EGF) to enhance skin cell proliferation and regeneration.

Conflicts

  • High heat
  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

Specific CIR, SCCS, or FDA safety statuses for the combined ingredient 'METHIONYL SH-POLYPEPTIDE-7 SH-OLIGOPEPTIDE-1 SH-OLIGOPEPTIDE-2' are not explicitly available. For SH-Oligopeptide-1, regulatory data is noted as unavailable with 'unknown long-term risks' despite its authorization for general cosmetic use. While considered mitogenic (stimulates cell proliferation) but not mutagenic (does not alter cells to become cancerous), significant caution is advised. This ingredient has the potential to promote the spread of *existing* cancerous cells, making it unsuitable for individuals with skin cancer risk factors or active psoriasis. Furthermore, a general caution applies to all growth factor-mimicking peptides, including SH-Oligopeptide-2, due to potential correlation with tumorigenesis or progression, with recombinant IGF-1 specifically linked to melanoma progression.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Questionable

While demonstrating significant potential for skin regeneration, anti-aging, and texture improvement, the ingredient's classification as mitogenic and documented association with promoting existing cancerous cells necessitates cautious consideration for a precision skincare brand, especially given insufficient long-term safety data for the combined complex and its components.

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