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Moumoujus

METHIONYL HEXAPEPTIDE-40 SH-DECAPEPTIDE-1 TRIPEPTIDE-44 RH-POLYPEPTIDE-3.

Insufficient Data / SKIN CONDITIONING

This intricate recombinant fusion peptide acts as a multifaceted skin conditioning agent. It is engineered to rejuvenate the skin by signaling internal repair mechanisms, targeting a range of photoaging concerns from fine lines to firmness and overall radiance.

Summary

skin conditioning anti-aging moisturizing anti-blemish

Science

Mechanism of Action

METHIONYL HEXAPEPTIDE-40 SH-DECAPEPTIDE-1 TRIPEPTIDE-44 RH-POLYPEPTIDE-3 operates as a signaling peptide, activating the skin's endogenous repair processes. Specifically, it stimulates fibroblast growth and proliferation, crucial for the synthesis of extracellular matrix components like collagen and elastin. This action fortifies skin structure, enhances tone and elasticity, and mitigates the appearance of fine lines and wrinkles. Furthermore, related hexapeptides suggest potential roles in regulating melanin synthesis, which could help diminish hyperpigmentation, and in offering protection against environmental stressors.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In a 12-week study, formulations containing active peptide complexes significantly enhanced skin hydration by 28.12%, elasticity by 18.81%, and stimulated collagen production by 54.99%.
  2. 02 An anti-aging regimen utilizing tripeptide/hexapeptide formulations resulted in an average 33% improvement across visual signs of facial photoaging, including fine lines, firmness, plumpness, and sagginess, over 12 weeks. Overall skin radiance improved by 44%.

Transparency

Dusting Analysis

Not commonly dusted

There is no specific data available to suggest this complex peptide is commonly 'dusted' or used in ineffectually low concentrations for marketing purposes.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

This peptide is most stable in lyophilized form. Once reconstituted, it should be stored frozen in aliquots to prevent degradation from freeze-thaw cycles. Prolonged exposure to pH levels above 8.0 should be strictly avoided. To maintain integrity, minimize atmospheric oxygen exposure, particularly for peptides containing methionine, cysteine, or tryptophan. Optimal dissolution is typically observed at a near-neutral pH (6-8) where the peptide exhibits a higher net charge, though some related fusion proteins have demonstrated stability up to pH 12.0.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not directly assessed the safety of METHIONYL HEXAPEPTIDE-40 SH-DECAPEPTIDE-1 TRIPEPTIDE-44 RH-POLYPEPTIDE-3 as a complete complex. While simpler, related peptides such as Tripeptide-1, Hexapeptide-12, and Acetyl Hexapeptide-8 Amide have been deemed safe at low concentrations (e.g., < 10 ppm and up to 0.005% respectively), these findings do not directly apply to this complex. Other bodies, including Paula's Choice and the SCCS, also indicate a lack of specific review for this or very similar complex peptides. No specific FDA status is recorded.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While exhibiting compelling clinical results for skin rejuvenation and conditioning, the absence of a direct safety review for this specific complex peptide necessitates caution and further evaluation.

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