Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE.

Valuable CAS 67881-98-5 / NOT REPORTED

Methacryloyloxyethyl Phosphorylcholine (MPC) is a sophisticated biomimetic ingredient engineered to profoundly enhance skin hydration and reinforce barrier function. By forming an artificial cell membrane-like structure, it creates a robust, highly hydrated surface on the skin, effectively shielding against environmental aggressors and preventing moisture loss.

Summary

moisturizer film former skin conditioning barrier repair

Science

Mechanism of Action

This ingredient operates by constructing a cell membrane-mimicking structure that maintains an intensely hydrated surface under biological conditions. This strong hydration layer actively inhibits the adsorption of proteins and lipid molecules, thereby stabilizing the skin's natural barrier. On the skin, it critically prevents the disruption of the stratum corneum's inter-lamellar bilayer structure, even during extensive skin hydration, and has been shown to reduce inflammatory IL-8 production.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

3%

Key findings

  1. 01 A 3% concentration significantly decreased nicotinic acid permeation and preserved the skin barrier by preventing the disruption of the inter-lamellar bilayer structure during extensive skin hydration.
  2. 02 MPC-type zwitterionic polymers exhibited pronounced antibiofouling properties, resulting in a 50% reduction in fibrinogen adsorption and an 80% decline in fibroblast adhesion.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7.3
0 7 14

Stability

Poly(MPC) polymers are soluble in aqueous buffers within a pH range of 4.0 to 7.3, with water solubility reported between 83-86 vol% at 20°C and pH 5.9-6.8. The monomer is hygroscopic, requiring care during synthesis due to potential purity issues with trace water. Higher molecular weight MPC polymers demonstrate enhanced stability in biological conditions, resisting enzymatic or hydrolytic degradation and ensuring prolonged efficacy.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Panel has affirmed the safety of acryloyloxyethyl phosphorylcholine polymers, including derivatives of Methacryloyloxyethyl Phosphorylcholine, for use in cosmetics under current practices. Due to their substantial molecular weights, significant skin penetration by these polymers is not expected. However, it is important to note that the monomer (2-methacryloyloxyethyl phosphorylcholine) is classified with a GHS hazard statement H317, indicating potential for allergic skin reactions (Skin Sens. 1). A specific MPC polymer (Lipidure®-CM5206) is also registered in US FDA Master Files for Devices, underscoring its established medical applicability and safety in certain contexts.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

As a biomimetic moisturizer and barrier fortifier, Methacryloyloxyethyl Phosphorylcholine is a valuable asset for enhancing skin hydration and resilience, particularly for dry and sensitive skin types.

Related

Similar Ingredients

Finding similar ingredients…