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Moumoujus

MERCAPTOPROPYLTRIMETHOXYSILANE.

Avoid CAS 4420-74-0 / NAIL CONDITIONING

MERCAPTOPROPYLTRIMETHOXYSILANE (MPTMS) acts as a molecular linker, primarily employed in industrial settings for adhesion promotion and surface modification. It is characterized by its trimethoxysilane groups, which hydrolyze in the presence of water, and a mercaptopropyl group that provides an anchoring point for other molecules. A significant safety consideration is its reaction with water or moisture, which leads to the liberation of toxic methanol.

Summary

Science

Mechanism of Action

While its specific mechanism on human skin is not documented, MERCAPTOPROPYLTRIMETHOXYSILANE functions as a molecular linker. Its trimethoxysilane components undergo hydrolysis upon contact with water, forming silanol groups (Si-OH) that can covalently bond with oxide surfaces. Concurrently, its mercaptopropyl group, which contains a thiol (-SH) functionality, serves as an anchor, facilitating the attachment of various molecules to modify surface properties. These properties are primarily leveraged for industrial adhesion and surface modification rather than direct skin application.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest MERCAPTOPROPYLTRIMETHOXYSILANE is commonly 'dusted' in cosmetic formulations, nor are there relevant thresholds or red flag percentages provided in the research for this application.

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 5
0 7 14

Stability

MERCAPTOPROPYLTRIMETHOXYSILANE exhibits stability in sealed, anhydrous containers. However, it is highly reactive with water and atmospheric moisture, leading to the hydrolysis of its silane groups and the subsequent release of methanol. For optimal hydrolysis and condensation reactions of organosilanes, a precise pH range of 4 to 5 is recommended. pH values below 4 may accelerate hydrolysis but hinder condensation, while values above 5 can slow hydrolysis but accelerate condensation, potentially causing premature polymerization and precipitation.

Conflicts

  • Moisture
  • Water
  • Strong oxidizing agents
  • Strong acids
  • Alcohols

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

MERCAPTOPROPYLTRIMETHOXYSILANE is classified as harmful if swallowed (H302), may cause an allergic skin reaction (H317), and causes serious eye irritation (H319). It is considered a mild skin irritant and a strong eye irritant. A critical safety concern is its degradation in the presence of water or moisture, which liberates methanol, a toxic substance. Chronic exposure to methanol can adversely affect the central nervous system. Additionally, this ingredient is toxic to aquatic life.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Considering its significant safety hazards, including the release of toxic methanol upon contact with moisture, inherent irritancy, potential for allergic reactions, and the complete absence of identified cosmetic benefits or clinical data for skin application, MERCAPTOPROPYLTRIMETHOXYSILANE is unsuitable for precision skincare formulations and should be avoided.

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