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Moumoujus

MENTHYL SUCCINATE.

Valuable CAS 77341-67-4 / ASTRINGENT

Menthyl Succinate is an ester derivative of menthol, engineered to provide a sustained cooling sensation on the skin. Beyond its refreshing effect, it also functions as an astringent, contributing to a refined skin feel. This ingredient is valued for its stability and reduced volatility compared to traditional menthol.

Summary

Astringent Cooling Agent

Science

Mechanism of Action

As a menthyl ester, Menthyl Succinate emulates menthol's action by influencing cold receptors, specifically interfering with calcium ion movement across cell membranes. This process generates a physiological sensation of coolness upon topical application. Additionally, it promotes cutaneous vasodilation through mechanisms involving nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF), and sensory nerve pathways. In cosmetic formulations, it is also recognized for its astringent properties, helping to tighten and tone the skin.

Research

Clinical Evidence

Medium confidence
Effective range 0.001–85%
Optimal

0.1%

Key findings

  1. 01 Google Patents (EP2129234A1) highlights its contribution to cooling sensations in compositions, specifying effective ranges, with a preferred optimal range of 0.10% to 5% by weight.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Menthyl Succinate demonstrates notable stability and compatibility with diverse cosmetic ingredients, facilitating its seamless integration into formulations. Its lower volatility compared to menthol also contributes to enhanced product longevity and performance.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While classified with a hazard statement H318 ('Causes serious eye damage'), Menthyl Succinate has been recognized as a 'Flavoring Agent or Adjuvant' by the FDA (GRAS). The Joint FAO/WHO Expert Committee on Food Additives (JECFA) evaluated it in 1998, determining 'No safety concern at current levels of intake when used as a flavouring agent', indicating a history of safe use in other industries.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Menthyl Succinate is a valuable cooling and astringent agent, offering enhanced stability and reduced volatility compared to menthol, making it suitable for formulations targeting a refreshing sensation.

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