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Moumoujus

MEA O-PHENYLPHENATE.

Avoid CAS 84145-04-0 / ANTIMICROBIAL

MEA O-Phenylphenate is an antimicrobial agent historically used as a preservative in cosmetic formulations. However, due to significant safety concerns regarding its enhanced skin penetration and potential toxicity, it has been banned for cosmetic use in the EU since September 2019.

Summary

preservative

Science

Mechanism of Action

This compound functions by inhibiting microbial proliferation, thereby acting as a preservative. Research indicates that the monoethyleneamine (MEA) moiety facilitates greater skin absorption compared to its parent compound, o-phenylphenol, which is posited to heighten its potential for toxic effects.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

MEA O-Phenylphenate is not an active ingredient commonly associated with 'dusting' due to its primary role as a preservative and its regulatory status, rendering concentration optimization for efficacy irrelevant in cosmetic contexts.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Direct stability data for MEA O-Phenylphenate is not specified. However, related o-phenylphenate salts are known to dissociate to o-phenylphenol (the free acid) within the common environmental pH range of 4 to 9. O-phenylphenol itself demonstrates stability at pH 5, 7, and 9.

Conflicts

  • Prohibited for use as a preservative in cosmetic products within the European Union due to safety concerns and regulatory mandates (effective September 17, 2019).
  • As a monoalkanolamine salt, its inclusion is subject to general EU cosmetic regulations governing monoalkylamines and monoalkanolamines, which restrict the total secondary amine content to a maximum of 0.5% in ready-for-use cosmetic preparations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

MEA O-Phenylphenate is banned as a cosmetic preservative in the EU since September 17, 2019. Regulatory bodies, such as the SCCS, have been unable to establish safe use levels, citing insufficient relevant data. Concerns are heightened by its demonstrated greater skin penetration and the potential for increased toxicity compared to o-phenylphenol, partly attributed to the MEA moiety.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

MEA O-Phenylphenate is a prohibited cosmetic ingredient in the EU with high irritancy potential and unresolved safety concerns, making it unsuitable for skincare formulations.

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