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Ingredient directory

Mea-biotinate

MEA-BIOTINATE is an ingredient derived from biotin, also known as Vitamin B7 or H, primarily recognized for its skin conditioning properties. It is designed to help maintain the skin's healthy appearance and overall condition.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

Skin-Conditioning Agent Hair Conditioning

Science

Mechanism of Action

While the precise topical mechanism of MEA-BIOTINATE is not extensively detailed, its functionality stems from its biotin base. Biotin is a crucial water-soluble vitamin and coenzyme, participating in essential biological processes such as fatty acid synthesis, gluconeogenesis, and amino acid metabolism, which are vital for cellular integrity. As a skin conditioning agent, it contributes to the general maintenance and vitality of the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data available to suggest this ingredient is commonly dusted or has associated dusting thresholds.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 9
0 7 14

Stability

Biotin, the core component of MEA-BIOTINATE, exhibits good stability to air and temperature. Solutions in moderately acidic to neutral pH ranges (pH 5-8) are stable for several months, with minimal losses (0-8%) observed over a year at room temperature. Alkaline solutions remain reasonably stable up to pH 9. As a biotin salt, MEA-BIOTINATE is expected to share this water-soluble characteristic.

Conflicts

  • N-nitrosating agents (due to potential nitrosamine formation)

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
5%
Sensitization risk Unknown

The CIR Expert Panel found Biotin itself safe for cosmetic use, with a maximum reported leave-on concentration of 0.1%. However, MEA-BIOTINATE, as an ethanolamine-containing ingredient, is subject to specific restrictions. For prolonged skin contact, the concentration of ethanolamines should not exceed 5%. Furthermore, European regulations (EC Cosmetics Regulation Annex III, following SCCS assessment) restrict its use to prevent the formation of harmful N-nitrosamines when formulated with N-nitrosating agents, necessitating careful formulation considerations.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While offering skin conditioning benefits derived from biotin, MEA-BIOTINATE's formulation presents significant challenges due to critical restrictions against nitrosamine formation and a lack of specific topical efficacy data.

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