Science
Mechanism of Action
This ingredient's manganese component is recognized for its capacity to shield human skin fibroblasts from oxidative injury induced by UV-A radiation and hydrogen peroxide. Its fructose diphosphate component, specifically fructose 1,6-diphosphate, has been shown to mitigate UVB-induced oxidative stress by preserving the skin's inherent antioxidant defenses, such as catalase and glutathione, while preventing the accumulation of carbonylated proteins. Furthermore, fructose 1,6-diphosphate has demonstrated an ability to influence desmosomes and enhance collagen fiber density in skin equivalents.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While specific stability data for Manganese Fructose Diphosphate are not available, the fructose component is susceptible to decomposition in alkaline environments. Consequently, substances that elevate the pH above 7 should not be incorporated into formulations.
Conflicts
- calcium in alkaline solutions (pH > 7)
- barium in alkaline solutions (pH > 7)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that the available data are insufficient to ascertain the safety of Manganese Fructose Diphosphate for its use in cosmetics. According to VCRP and Council survey data, this ingredient is not presently utilized in cosmetic products within the U.S.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to insufficient safety data and a lack of clinical studies regarding its efficacy and usage in cosmetics, its application is currently not recommended.
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References
Sources