Science
Mechanism of Action
As a vital cofactor, manganese ions are integral to enzymatic reactions, notably activating manganese-superoxide dismutase (Mn-SOD), a powerful antioxidant enzyme that detoxifies free radicals, thereby protecting skin from premature aging and cellular damage. It also exhibits anti-inflammatory properties, which may alleviate conditions like acne and eczema by reducing redness and swelling. Furthermore, manganese is proposed to promote wound healing and collagen synthesis through the activation of enzymes involved in collagen formation, which enhances skin barrier function and elasticity. A patent suggests its ability to influence calcium channels, potentially leading to tissue relaxation and a reduction in wrinkles and fine lines.
Research
Clinical Evidence
Low confidence0.001-5%
Key findings
- 01 Proposed for reducing wrinkles and fine lines by affecting skin/subcutaneous tissue relaxation, noted in a patent (JP2002003387A). This is a patent claim and not a human clinical study.
- 02 Stimulated LOX gene expression in plant cell cultures (Eschscholzia californica Cham), observed at 5 mg/L. This study is not on human skin and its relevance is limited.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Hydrates of Manganese(II) chloride form mildly acidic solutions (pH ~4) in water. Manganese(II) may undergo oxidation by air to form Mn(III) complexes when treated with typical organic ligands, suggesting potential instability. It can also form other manganese chloride complexes with excess chloride ions.
Conflicts
- Potential oxidation by air in the presence of organic ligands
Safety
Safety Profile
Manganese Chloride is deemed safe for specific, limited food uses by the US FDA. However, its cosmetic safety profile is complex. EWG Skin Deep rates it 'LOW' for cancer, allergies, and developmental toxicity but 'high' for non-reproductive organ system toxicity, identifying it as a 'known human respiratory toxicant'. Safety Data Sheets (SDS) indicate it is 'Toxic if swallowed' and 'Causes serious eye damage' (with risk of blindness), classifying it as an irritant for skin and eyes, with potential for organ (brain) damage from prolonged or repeated exposure. In contrast, SkinSAFE lists it as 'Teen SAFE', 'Lip SAFE', 'Baby SAFE', 'Eyelid SAFE', and 'Irritant Free' in cosmetic contexts. No specific maximum concentration for cosmetic use has been established by regulatory bodies like CIR or SCCS.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While Manganese Chloride shows theoretical promise for antioxidant, anti-inflammatory, and anti-aging benefits, the absence of robust human clinical studies and conflicting safety information warrants further investigation before broad cosmetic adoption.
Related
Similar Ingredients
Finding similar ingredients…