Science
Mechanism of Action
This extract operates through multiple pathways to benefit the skin. It exhibits anti-inflammatory activity by significantly inhibiting superoxide anion generation and elastase release in human neutrophils. Its essential oil component provides robust antioxidant protection by scavenging DPPH free radicals, and demonstrates antimicrobial action by suppressing the growth of Gram-positive bacteria and yeast. Furthermore, the presence of flavonoids within the extract augments its antioxidant capacity and inhibits low-density lipoprotein oxidation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 The essential oil from Machilus japonica leaves exhibited strong antioxidant activity with an IC50 of 51.8 µg/mL in a DPPH free radical scavenging test.
- 02 The essential oil from Machilus japonica leaves showed significant growth suppression against Gram-positive bacteria and yeast, with MIC values ranging from 16.12 to 32.25 µg/mL.
- 03 Lignans isolated from Machilus japonica var. kusanoi demonstrated inhibitory effects on fMLP/CB-induced superoxide anion generation in human neutrophils, with IC50 values for individual lignans ranging from 2.23 ± 0.92 μM to 8.71 ± 0.74 μM.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Machilus Japonica Extract has not been reviewed by the CIR, and research is ongoing. While related species may be considered safe, patch testing is recommended due to the potential for allergic reactions or sensitivity, particularly for sensitive skin types, as essential oil components are present.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Machilus Japonica Extract is a valuable ingredient, demonstrating potent antioxidant, anti-inflammatory, and antimicrobial properties through in vitro studies, despite current gaps in safety review and formulation data.
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References
Sources