New 50 ml glass bottles30-day money-back guarantee
Menu
Moumoujus

Ingredient directory

Machilus Japonica Extract

Machilus Japonica Extract is a botanical ingredient derived from the leaves of the Machilus japonica tree. It is valued for its comprehensive benefits, including potent antioxidant, anti-inflammatory, and antimicrobial properties, which contribute to enhanced skin health and protection.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

Antioxidant Anti-inflammatory Antimicrobial Skin conditioning

Science

Mechanism of Action

This extract operates through multiple pathways to benefit the skin. It exhibits anti-inflammatory activity by significantly inhibiting superoxide anion generation and elastase release in human neutrophils. Its essential oil component provides robust antioxidant protection by scavenging DPPH free radicals, and demonstrates antimicrobial action by suppressing the growth of Gram-positive bacteria and yeast. Furthermore, the presence of flavonoids within the extract augments its antioxidant capacity and inhibits low-density lipoprotein oxidation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 The essential oil from Machilus japonica leaves exhibited strong antioxidant activity with an IC50 of 51.8 µg/mL in a DPPH free radical scavenging test.
  2. 02 The essential oil from Machilus japonica leaves showed significant growth suppression against Gram-positive bacteria and yeast, with MIC values ranging from 16.12 to 32.25 µg/mL.
  3. 03 Lignans isolated from Machilus japonica var. kusanoi demonstrated inhibitory effects on fMLP/CB-induced superoxide anion generation in human neutrophils, with IC50 values for individual lignans ranging from 2.23 ± 0.92 μM to 8.71 ± 0.74 μM.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Machilus Japonica Extract has not been reviewed by the CIR, and research is ongoing. While related species may be considered safe, patch testing is recommended due to the potential for allergic reactions or sensitivity, particularly for sensitive skin types, as essential oil components are present.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Machilus Japonica Extract is a valuable ingredient, demonstrating potent antioxidant, anti-inflammatory, and antimicrobial properties through in vitro studies, despite current gaps in safety review and formulation data.

Related

Similar Ingredients

Finding similar ingredients…

Keep exploring

From ingredients to everyday care.

Sensitive skin ↗

Start with comfort, product choices and the questions to ask.

Barrier support ↗

Understand moisture, lipids and the limits of ingredient claims.

Ingredient names help you read a label. They do not establish how a finished product will perform. Explore The Garden.