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Moumoujus

MACARANGA TANARIUS LEAF EXTRACT.

Insufficient Data CAS - / SKIN CONDITIONING

Macaranga Tanarius Leaf Extract is a botanical ingredient rich in a diverse array of polyphenolic compounds, offering notable antioxidant and anti-inflammatory benefits. It functions as a skin conditioning agent, contributing to overall skin health and resilience.

Summary

Antioxidant Anti-inflammatory Skin Conditioning Antibacterial

Science

Mechanism of Action

The extract contains a complex profile of prenylflavonoids, other flavonoids, stilbenes, tannins, terpenes, and coumarins. These compounds exert their effects through mechanisms such as potent antioxidant activity by neutralizing free radicals, and anti-inflammatory action evidenced by inhibiting protein denaturation. This multi-component synergy helps to maintain the skin's good condition.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated significant inhibition of protein (albumin) denaturation (IC50 0.26–1.02 mM), indicating anti-inflammatory effects.
  2. 02 Exhibited notable antioxidant activity, assessed by Total Phenolic and Flavonoid Content.
  3. 03 Showed antibacterial activity against Gram-positive strains (using fruit extract).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Polyphenols within Macaranga Tanarius Leaf Extract are susceptible to degradation from heat and light, leading to low stability. Nanotechnology, including nanoemulsions and liposomes, is being investigated to enhance the stability of these bioactive compounds in cosmetic formulations and potentially mitigate side effects.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

No direct safety assessments from CIR or SCCS were identified. While an acute toxicity study in rats using a hexane-ethanol fraction showed no toxic effects, a brine shrimp lethality test indicated moderate toxicity for leaf extracts (LC50 of ≥30–1000 µg/mL). As with many natural ingredients, there is a potential for allergic reactions or dermatitis. The possible presence of furocoumarins suggests a risk of phototoxicity, making nighttime application advisable.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Macaranga Tanarius Leaf Extract demonstrates promising anti-inflammatory and antioxidant properties, comprehensive clinical data for optimal topical efficacy and a definitive safety profile are currently insufficient for its precise application in advanced skincare.

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