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Moumoujus

MAACKIASIN.

Avoid CAS 103147-87-1 / HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

Maackiain, referred to here as MAACKIASIN, is a cyclized isoflavonoid exhibiting diverse biological activities. It is recognized for its potent anti-inflammatory, antiallergenic, and antioxidant properties, alongside potential effects on skin pigmentation and antimicrobial actions.

Summary

Anti-inflammatory Antiallergenic Antioxidant Potential skin brightening

Science

Mechanism of Action

MAACKIASIN operates through multiple pathways to exert its effects. It effectively inhibits increases in mRNA encoding the histamine H1 receptor and interleukin-4 (Il-4), crucial mediators in allergic responses. Furthermore, it reduces LPS-induced nitric oxide (NO) production in macrophages and influences immune signaling by enhancing NLRP3 inflammasome activation while inhibiting the NF-κB pathway. Its antioxidant capacity stems from strong radical scavenging activities and the inhibition of iNOS and NADPH oxidase. For skin brightening, MAACKIASIN is noted to inhibit melanogenesis-related enzymes, promote melanosome degradation via autophagy, and restrict melanosome endocytosis into keratinocytes.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Inhibits increases in mRNA encoding the histamine H1 receptor in vitro.
  2. 02 Inhibits PMA-induced increases in mRNA encoding Il-4 in RBL-2H3 cells in vitro.
  3. 03 Decreases LPS-induced increases in nitric oxide (NO) production in RAW 264.7 macrophages in vitro.
  4. 04 Increases survival in a mouse model of sepsis.
  5. 05 Reduces allergic symptoms (sneezing, nasal redness, swelling, watery rhinorrhea) in a rat model of allergies.

Transparency

Dusting Analysis

Not commonly dusted

MAACKIASIN is primarily identified as a research chemical, generally not intended or recommended for human or veterinary use. Its potent biological activities have not been evaluated for safe topical cosmetic application.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The compound is stable for at least 4 years when stored at -20°C, with stability also noted at 2-8°C.

Conflicts

  • Not recommended for human topical application due to documented irritancy.
  • Requires specific organic solvents for dissolution (e.g., acetonitrile, chloroform, dichloromethane, ethyl acetate, DMSO, acetone). Can be suspended in 0.5% CMC-Na/saline water with ultrasonic aid.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

MAACKIASIN is explicitly labeled 'not for human or veterinary use' by chemical suppliers and is intended for laboratory use only. Chemical safety data indicates significant hazards, including GHS pictograms GHS07, with warning statements H315 (Causes skin irritation) and H319 (Causes serious eye irritation). There are no specific safety assessments from regulatory bodies like CIR or SCCS for cosmetic application.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite promising in vitro and animal model data demonstrating anti-inflammatory, antiallergenic, and potential skin brightening effects, MAACKIASIN is expressly not recommended for human topical application due to documented high irritancy and a lack of cosmetic safety assessment.

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