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Moumoujus

M-CRESOL.

Questionable CAS 108-39-4 / ANTIMICROBIAL, PERFUMING

M-Cresol is an aromatic organic compound primarily employed in cosmetics as a preservative and fragrance component. It functions by disrupting microbial integrity through protein aggregation, effectively inhibiting bacterial and fungal growth, but requires stringent concentration control due to its potent activity and potential for skin irritation.

Summary

Preservative Biocide Fragrance Ingredient

Science

Mechanism of Action

M-Cresol exerts its antimicrobial effects by inducing protein aggregation within microbial cells. This denaturation process disrupts essential cellular functions, thereby inhibiting the proliferation of bacteria and fungi and ensuring product stability.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

M-Cresol is susceptible to degradation, evidenced by darkening upon prolonged exposure to light and air, which can impact formulation integrity.

Conflicts

  • Significantly enhances the dermal penetration of other cosmetic ingredients, necessitating careful assessment of co-formulated actives.
  • Its inherent corrosive properties mandate specialized handling and formulation procedures to ensure safety and product integrity.
  • Degrades upon exposure to light and air, manifesting as discoloration, which can compromise product aesthetics and stability.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.5%
Sensitization risk Moderate

The CIR Expert Panel restricts m-Cresol to a maximum concentration of 0.5% in cosmetic products to prevent potential chemical leukoderma (skin whitening). It is known to increase the dermal penetration of co-applied ingredients. Direct contact can result in severe skin and respiratory irritation, including second-degree burns and damage to mucous membranes. A moderate risk of skin sensitization exists. While related compounds like Thymol are FDA-approved for other uses, specific SCCS opinions for m-Cresol in skincare are not comprehensively available.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

M-Cresol offers potent preservative action but carries significant safety liabilities, including irritation, sensitization, and the potential for chemical leukoderma, which severely limits its suitability for precision skincare formulations.

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