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LYSINE DNA.

Valuable / SKIN CONDITIONING

Lysine DNA is a sophisticated active ingredient combining the structural and regenerative benefits of the essential amino acid Lysine with the protective capabilities of DNA derivatives. It works to fortify collagen, enhance skin hydration and barrier function, reduce inflammation, and may protect against environmental damage. Specific dendrimer forms also contribute to rebalancing skin microbiota.

Collagen Synthesis Support Skin Strengthening Moisturizing Skin Regeneration Anti-inflammatory Barrier Function Enhancement Acne Reduction DNA Repair UV Protection (indirect, via repair) Free Radical Protection Microbiota Rebalancing Antimicrobial

Science

Lysine, an essential amino acid, is fundamental for the robust formation and stabilization of collagen's triple-helix structure by enabling cross-links, thereby enhancing skin's resilience. It supports critical enzymes like lysyl oxidase, vital for collagen synthesis. Beyond its structural role, Lysine promotes skin hydration, aids regeneration, exhibits anti-inflammatory properties to soothe redness, and strengthens the skin's barrier. It may also help minimize acne by boosting carnitine synthesis. Simultaneously, nucleic acids and their derivatives, such as DNA, facilitate cellular self-repair to mend damaged DNA and provide protection against UV radiation and free radical damage. Lysine-based dendrimers further bind to bacterial cell surfaces, demonstrating bactericidal activity, rebalancing the skin's microbiota, and enhancing anti-inflammatory effects. These dendrimers can also improve the stability and liposolubility of other cosmetic actives like Vitamin C.


Research

Medium confidence
Effective range N/A
Optimal

0.4%

Key findings

  1. 01 A G2-dendrimer of lysine significantly decreased signs of acne and rebalanced the cutaneous microbiota in volunteers with acne-prone skin.

Transparency

Not commonly dusted

No data available regarding dusting behavior for this ingredient.


The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Poly-L-lysine (PLL) dendrimer vectors have been shown to enhance the stability of Vitamin C in dermocosmetic formulations, maintaining stable pH and color under normal storage conditions. Lysine, as a raw material, exhibits stability under high heat settings and assists in the gelation of solvents. The specific conformation of poly-l-lysine is influenced by factors such as pH, temperature, ionic strength, and solvent type.

Synergies

  • Vitamin C (enhanced stability)

Safety

CIR Status
Safe as used
Max tested
45%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that α-amino acids, including lysine, are safe as cosmetic ingredients in reported uses and concentrations. Lysine is also generally recognized as safe (GRAS) by the FDA as a direct food additive, and toxicity is rare even at high oral doses.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

Lysine DNA is a valuable ingredient, leveraging an essential amino acid and DNA derivatives to offer comprehensive benefits from collagen support and hydration to microbiota rebalancing and cellular repair, with demonstrated safety.


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