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Moumoujus

LYSINE.

Valuable CAS 56-87-1 / ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING

Lysine is an essential alpha-amino acid, fundamental for numerous biological processes crucial to robust skin health. Topically, it is recognized for its vital role in supporting collagen architecture, enhancing skin hydration, and facilitating tissue regeneration.

Summary

Amino Acid Collagen Booster Hydration Skin Repair Barrier Support Oil Regulation (potential) Anti-inflammatory (potential)

Science

Mechanism of Action

As an essential amino acid, Lysine acts as a vital precursor and co-factor in the skin's structural integrity. It directly supports collagen synthesis by aiding lysyl oxidase, an enzyme critical for cross-linking collagen fibers, thereby contributing to dermal elasticity and firmness. Beyond structural support, topical application may bolster the skin's barrier function and optimize water transport through skin layers, leading to enhanced hydration. Furthermore, it exhibits potential anti-inflammatory properties and may contribute to balanced sebum production by influencing carnitine synthesis, potentially minimizing acne.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A 15% topical concentration demonstrated improved wound healing in patients with diabetic foot ulcers.
  2. 02 Oral supplementation (concentration unspecified, in combination with other amino acids) over 12 weeks enhanced skin hydration, hair strength, and nail health.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Lysine can contribute to improved product adherence and extend wear time. Its derivative, Poly-L-lysine, has been shown to enhance the stability of Vitamin C in dermocosmetic formulations. It generally maintains stability under high heat, although this attribute is often associated with its derivative, Lauroyl Lysine.

Synergies

  • Vitamin C (with Poly-L-lysine derivative)
  • Other amino acids

Conflicts

  • Strong acids
  • High concentrations of arginine

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.7%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has approved Lysine for safe topical use in personal care products at concentrations up to 0.7%. It is important to note that its derivative, Lauroyl Lysine, has a higher approved concentration of up to 45%. While L-amino acids are generally recognized as safe (GRAS) by the FDA as direct food additives, specific FDA status for Lysine's topical cosmetic use is unavailable.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Lysine is a valuable essential amino acid that fundamentally supports skin structure through collagen synthesis, enhances hydration and barrier function, and offers broad compatibility for all skin types due to its low irritancy profile within regulatory limits.

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References

Sources